• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >N-acetylcysteine prevents stress-induced anxiety behavior in zebrafish
【24h】

N-acetylcysteine prevents stress-induced anxiety behavior in zebrafish

机译：N-乙酰琥珀酸氨酸可防止斑马鱼中的应力引起的焦虑行为

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Despite the recent advances in understanding the pathophysiology of anxiety disorders, the pharmacological treatments currently available are limited in efficacy and induce serious side effects. A possible strategy to achieve clinical benefits is drug repurposing, i.e., discovery of novel applications for old drugs, bringing new treatment options to the market and to the patients who need them. N-acetylcysteine (NAC), a commonly used mucolytic and paracetamol antidote, has emerged as a promising molecule for the treatment of several neuropsychiatric disorders. The mechanism of action of this drug is complex, and involves modulation of antioxidant, inflammatory, neurotrophic and glutamate pathways. Here we evaluated the effects of NAC on behavioral parameters relevant to anxiety in zebrafish. NAC did not alter behavioral parameters in the novel tank test, prevented the anxiety-like behaviors induced by an acute stressor (net chasing), and increased the time zebrafish spent in the lit side in the light/dark test. These data may indicate that NAC presents an anti-stress effect, with the potential to prevent stress-induced psychiatric disorders such as anxiety and depression. The considerable homology between mammalian and zebrafish genomes invests the current data with translational validity for the further clinical trials needed to substantiate the use of NAC in anxiety disorders. (C) 2015 Elsevier Inc All rights reserved.
机译：尽管最近理解焦虑症的病理生理学进展，目前可用的药理学治疗有限，疗效有限，诱导严重的副作用。实现临床效益的可能策略是药物重估，即发现对旧药物的新申请，为市场和需要它们的患者带来新的治疗方案。 N-乙酰半胱氨酸（NAC）是一种常用的粘液溶解和扑热氨基醇解毒剂，作为治疗几种神经精神疾病的有希望的分子。该药物的作用机制是复杂的，涉及调节抗氧化剂，炎症，神经营养和谷氨酸途径。在这里，我们评估了NAC对斑马鱼焦虑相关的行为参数的影响。 NAC没有改变新型罐试验中的行为参数，阻止了急性压力源（净追逐）引起的类似焦虑的行为，并增加了在光/暗试验中点亮侧面花费的时间斑马鱼。这些数据可能表明NAC具有抗应力效应，有可能防止应激诱导的精神病疾病如焦虑和抑郁症。哺乳动物和斑马鱼基因组之间的同一同源性投入了当前数据，具有转化有效性，以便在焦虑症中证实使用NAC的进一步临床试验。 （c）2015年elsevier inc保留所有权利。

著录项

  • 来源
  • 作者

    Mocelin Ricieri; Herrmann Ana P.; Marcon Matheus; Rambo Cassiano L.; Rohden Aline; Bevilaqua Fernanda; de Abreu Murilo Sander; Zanatta Leila; Elisabetsky Elaine; Barcellos Leonardo J. G.; Lara Diogo R.; Piato Angelo L.;

  • 作者单位

    Univ Comunitaria Regiao Chapeco Programa Posgrad Ciencias Ambientais BR-89809000 Chapeco SC;

    Univ Fed Rio Grande do Sul Programa Posgrad Ciencias Biol Bioquim BR-90035000 Porto Alegre RS;

    Univ Comunitaria Regiao Chapeco Programa Posgrad Ciencias Ambientais BR-89809000 Chapeco SC;

    Pontificia Univ Catolica Rio Grande do Sul Lab Neuroquim &

    Psicofarmacol Programa Posgrad Biol;

    Univ Comunitaria Regiao Chapeco Programa Posgrad Ciencias Ambientais BR-89809000 Chapeco SC;

    Univ Comunitaria Regiao Chapeco Programa Posgrad Ciencias Ambientais BR-89809000 Chapeco SC;

    Univ Fed Santa Maria Programa Posgrad Farmacol BR-97105900 Santa Maria RS Brazil;

    Univ Comunitaria Regiao Chapeco Programa Posgrad Ciencias Ambientais BR-89809000 Chapeco SC;

    Univ Fed Rio Grande do Sul Programa Posgrad Ciencias Biol Bioquim BR-90035000 Porto Alegre RS;

    Univ Fed Santa Maria Programa Posgrad Farmacol BR-97105900 Santa Maria RS Brazil;

    Pontificia Univ Catolica Rio Grande do Sul Lab Neuroquim &

    Psicofarmacol Programa Posgrad Biol;

    Univ Fed Rio Grande do Sul Lab Psicofarmacol &

    Comportamento Programa Posgrad Farmacol &

    Terapeut;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药理学;
  • 关键词

    N-acetylcysteine; Anxiety; Stress; Zebrafish;

    机译：n-乙酰琥珀酸;焦虑;压力;斑马鱼;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号