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Vaporized Cannabis differentially modulates sexual behavior of female rats according to the dose

机译：汽化大麻差异地根据剂量调节雌性大鼠的性行为

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Studies exploring the effect of compounds that modulate the endocannabinoid system on sexual behavior have yielded contradictory results. However, the effect of smoked Cannabis in women has been consistently associated with an increase in sexual drive. Therefore, it can be speculated that vaporized Cannabis will augment sexually motivated components of the sexual behavior of female rats. To test this hypothesis, we compared the sexual behavior of late-proestrous female rats in a bilevel chamber after vaporizing 0, 200 or 400 mg of Cannabis flowers (containing 18% of delta-9-THC and undetectable levels of cannabidiol) during 10 min. We found that both doses of Cannabis increased the duration of the lordosis response, whereas the highest dose also reduced the lordosis quotient of females. The lowest dose of Cannabis augmented the display of hops and darts without altering the expression of sexual solicitations of females, while the highest one did not affect the expression of hops and darts but reduced sexual solicitations. These effects were not accompanied by alterations of females' ambulatory behavior. The increment of the duration of lordosis response produced by both doses of Cannabis could be associated to a general effect of this drug in sensory processing, as can be an enhancement of females' sensory reactivity to males stimulation. However, the reduction in the display of solicitations and lordosis in response to mounting observed in females exposed to the highest dose when compared to control and 200 mg of Cannabis groups indicates a reduction of sexual receptivity and motivation. This differential effect of vaporized Cannabis according to the dose employed, suggests that it modulates sexual behavior in a complex way, impacting neural circuits that control different aspects of this social behavior.
机译：探索调节内胆碱系统对性行为的化合物的影响产生了矛盾的结果。然而，烟熏大麻在女性中的影响一直与性驱动增加一致。因此，可以推测蒸发的大麻将增加雌性大鼠性行为的性促进的组分。为了测试这一假设，在10分钟期间，我们将在蒸发0,200或400mg大麻花（含有18％的Delta-9-THC和未检测水平的Cancabidiol）后胆汁室中的晚期不甲壳中的性行为进行比较。我们发现，两种剂量的大麻增加了雄小角反应的持续时间，而最高剂量也会降低了女性的脊髓植物。最低剂量的大麻增强了啤酒花和飞镖的展示，而不改变女性的性征求性的表达，而最高的人不会影响啤酒花和飞镖的表达，而是减少性征集。这些效果不伴随着女性的动态行为的改变。两种剂量大麻产生的脊柱源响应持续时间的增量可能与这种药物在感官加工中的一般效果相关，因为可以提高女性对雄性刺激的感觉反应性。然而，与对照相比，在暴露于最高剂量和200毫克大麻组的女性中观察到的谋取和雄蕊的显示的减少表明性接受性和动机的减少。汽化大麻根据所用剂量的这种差异效果表明它以复杂的方式调节性行为，影响控制这种社会行为的不同方面的神经电路。

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