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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Single nucleotide polymorphisms, variable number tandem repeats and allele influence on serotonergic enzyme modulators for aggressive and suicidal behaviors: A review
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Single nucleotide polymorphisms, variable number tandem repeats and allele influence on serotonergic enzyme modulators for aggressive and suicidal behaviors: A review

机译：单核苷酸多态性，可变数串联重复和等位基因对腐蚀性和自杀行为进行血清奈奈能酶调节剂的影响：综述

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摘要

The serotonergic system plays key regulatory roles in cognition and emotion. Several lines of evidence suggest that genetic variation is associated with aggressive and suicidal behaviors. Genetic studies have largely focused on three types of variations: single nucleotide polymorphisms (SNPs), variable number tandem repeats (VNTRs), and alleles. 95 published papers (49 papers for aggression and 46 for suicide) were reviewed to summarize the impact of SNPs, VNTRs, and alleles of tryptophan hydroxylase (TPH, the rate-limiting enzyme in serotonin [5-HT] synthesis), 5-HT transporter (5-HTT), serotonergic receptors, monoamine oxidase (an enzyme that catalyzes 5-HT degradation) on aggression and suicidal behaviors. These study samples include healthy controls, psychiatric disease patients, and animal models. This article mainly reviews studies on the relationship between 5-HT transmissions and genetic variations involved in aggression (particularly impulsive aggression) or suicide in people with different ethnicities and psychiatric disorders. We found that most SNPs, VNTRs, and alleles exerted influences on aggression or suicide. Only A128C in TPH1, A138G in 5-HT2A, and L type in the VNTR of monoamine oxidase A (MAOA) affected both aggression and suicide. The associations between some genetic variations and aggression/suicide may be influenced by gender, age, ethnicity, psychiatric disease, and even parenting or prenatal stress. These findings may help clarify how genetic and environmental factors influence the development of aggressive and suicidal behaviors.
机译：Serotonergic系统在认知和情感中起着关键的监管作用。几种证据表明遗传变异与侵略性和自杀行为有关。遗传学研究在很大程度上聚焦了三种类型的变化：单核苷酸多态性（SNP），可变数串联重复（VNTRS）和等位基因。 95篇论文（49篇用于自杀的侵略和46篇），总结了SNP，VNTRS和羟色素（Serotonin [5-HT]合成中TPH）的SNP，VNTRS和等位基因的影响，5-HT转运蛋白（5-HTT），血清酮受体，单胺氧化酶（一种催化5-HT降解的酶）侵略和自杀行为。这些研究样本包括健康对照，精神病患者和动物模型。本文主要审查了对不同种族和精神病疾病的人们侵略（特别是冲动的侵略）或自杀中所涉及的5-HT传输和遗传变异的关系。我们发现大多数SNP，VNTRS和等位基因都对侵略或自杀的影响施加了影响。在单胺氧化酶A（MAOA）的VNTR中，仅在TPH1，5-HT2A中的TPH1，A138G和L型均为侵略和自杀。某些遗传变异和侵略/自杀之间的关联可能受到性别，年龄，种族，精神病疾病，甚至养育或产前压力的影响。这些调查结果可能有助于澄清遗传和环境因素如何影响侵略性和自杀行为的发展。

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  • 作者

    Xiang Chunchen; Liu Shaojiang; Fan Yutong; Wang Xinyue; Jia Yunbo; Li Liang; Cong Shuyan; Han Fang;

  • 作者单位

    China Med Univ Basic Med Univ Dept Histol &

    Embryol PTSD Lab Shenyang 110122 Liaoning Peoples;

    China Med Univ Basic Med Univ Dept Histol &

    Embryol PTSD Lab Shenyang 110122 Liaoning Peoples;

    China Med Univ Basic Med Univ Dept Histol &

    Embryol PTSD Lab Shenyang 110122 Liaoning Peoples;

    China Med Univ Basic Med Univ Dept Histol &

    Embryol PTSD Lab Shenyang 110122 Liaoning Peoples;

    China Med Univ Basic Med Univ Dept Histol &

    Embryol PTSD Lab Shenyang 110122 Liaoning Peoples;

    Peking Univ Sch Psychol &

    Cognit Sci Beijing Key Lab Behav &

    Mental Hlth Beijing 100080 Peoples;

    China Med Univ Shengjing Hosp Dept Neurol Shenyang 110004 Liaoning Peoples R China;

    China Med Univ Basic Med Univ Dept Histol &

    Embryol PTSD Lab Shenyang 110122 Liaoning Peoples;

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  • 正文语种 eng
  • 中图分类 药理学;
  • 关键词

    Violence; Aggression; Suicide; Serotoninergic system; MAOA;

    机译：暴力;侵略;自杀;血清奈诺肾上腺素系统;毛亚;

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