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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Energy drink constituents (caffeine and taurine) selectively potentiate ethanol-induced locomotion in mice
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Energy drink constituents (caffeine and taurine) selectively potentiate ethanol-induced locomotion in mice

机译：能量饮料成分（咖啡因和牛磺酸）在小鼠中选择性地促进乙醇诱导的运动

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Mixing alcohol with energy drinks has emerged as a popular trend over the last decade. However, epidemiological studies have found this consumption to be associated with increased hazards, such as binge drinking, increased alcohol-related harm and risk of developing alcohol use disorder. The mechanisms underlying these effects are not clear, but much attention has been attributed to caffeine. However, taurine, another common ingredient in energy drinks, has also been associated with the dopamine elevating properties of ethanol, and may in this respect contribute to the increased liability associated with the mixture of alcohol and energy drinks. In the present study we measured locomotor activity, a phenomenon previously linked to the dopamine activating and reinforcing properties of the drug, following acute systemic administration with caffeine (1, 5, 15, 30 mg/kg), taurine (30, 60, 300, 600 mg/kg) and ethanol (1.75, 2.5, 3.25 g/kg), alone or in combination. We found that ethanol and caffeine, but not taurine, increased locomotion compared to vehicle. In addition, when combined with ethanol, caffeine, but not taurine, increased the locomotor stimulatory effect of ethanol. Furthermore, the combination of caffeine and taurine were able to further enhance the ethanol-induced locomotor response. Eleven days of intermittent caffeine exposure produced a sensitized response to the caffeine-induced locomotion, but did not alter the additive effect produced by the combination of caffeine and taurine on ethanol-induced locomotion. Based on the present study we suggest that the combination of caffeine and taurine, at a specific dose range, enhances the locomotor stimulatory properties of ethanol, a phenomenon previously linked to the reinforcing properties of the drug.
机译：将酒精与能量饮料混合出现在过去十年中的流行趋势。然而，流行病学研究发现这种消费与增加的危害有关，例如狂犬病饮酒，增加酒精相关的危害和开发酒精使用障碍的风险。这些效果的机制尚不清楚，但很多关注归因于咖啡因。然而，牛磺酸，能量饮料中的另一种常见成分也与乙醇的多巴胺升高有关，并且在这方面可能有助于增加与酒精和能量饮料的混合物相关的责任。在本研究中，我们测量了运动活性，以前与多巴胺活化和增强药物的活性的现象，在急性全身给药后用咖啡因（1,5,15,30mg / kg），牛磺酸（30,60,300 600mg / kg）和乙醇（1.75,2.5,3.25g / kg），单独或组合。我们发现乙醇和咖啡因，但不是牛磺酸，与车辆相比增加了运动。此外，当与乙醇相结合时，咖啡因但不是牛磺酸，增加了乙醇的运动刺激作用。此外，咖啡因和牛磺酸的组合能够进一步增强乙醇诱导的运动应答。间歇性咖啡因暴露的11天产生对咖啡因诱导的运动的敏化反应，但没有改变通过咖啡因和牛磺酸在乙醇诱导的运动的组合产生的添加剂。基于本研究，我们建议在特定剂量范围内咖啡因和牛磺酸的组合增强了乙醇的运动刺激性质，其先前与药物增强性能相关的现象。

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