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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Age- and sex-related changes in the severity of physical and psychological dependence in morphine-dependent rats
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Age- and sex-related changes in the severity of physical and psychological dependence in morphine-dependent rats

机译：与性质依赖大鼠身体和心理依赖严重程度的年龄和性别有关的变化

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Gender- and age-dependent effects on the severity of morphine dependence are still controversial. The aim of this study was to investigate the effects of age and sex on the severity of physical and psychological dependence in morphine-dependent rats. The adult/aged male and female Wistar rats were chronically treated with bi-daily doses (10 mg/kg, at 12 h intervals) of morphine for 14 days. Then, rats were tested for the severity of physical dependence on morphine (spontaneous withdrawal signs), anxiety-like (the elevated plus maze), depressive-like (sucrose preference test) and grooming behaviors after spontaneous morphine withdrawal. We found that the morphine withdrawal signs decreased after 3 and 7 days of withdrawal in female and male rats respectively, while there was no significant difference in overall dependence severity between the two sexes or ages. Also, we found that the withdrawal of morphine led to increased anxiety, depression and obsessive-compulsive behavior in the D (dependent)/Adult male and female rats. Also, the D/aged female and male rats exhibited a reduction in depressive-like behavior than the D/Adult rats. Moreover, the D/female rats exhibited a decreased obsessive-compulsive behavior in both age groups than male rats. We conclude that age has no effect on the duration of withdrawal from morphine and overall dependence severity. While, the duration of withdrawal from morphine was lower in female than male rats. Our results showed a sex difference on the duration of morphine withdrawal and an age difference in the expression of psychological dependence on morphine. Thus, therapeutic strategies may be different for opiate-dependent individuals in physical and psychological dimensions.
机译：性别和年龄依赖性对吗啡依赖的严重程度仍然存在争议。本研究的目的是调查年龄和性别对吗啡依赖大鼠身心依赖严重程度的影响。将成人/老年的男性和女性Wistar大鼠慢性用双日剂量（10mg / kg，12小时间隔）吗啡治疗14天。然后，测试大鼠对吗啡（自发戒断症状），焦虑状（升高的加迷宫），抑郁症状（蔗糖偏好试验）和修饰行为在自发情况下戒断后的严重程度。我们发现，在女性和雄性大鼠的戒断后3至7天后的吗啡戒断症减少，而两种性别或年龄之间的整体依赖严重程度没有显着差异。此外，我们发现，随着D（依赖性）/成年男性和女性大鼠的焦虑，抑郁和强迫性行为增加了吗啡的戒断。而且，D /老化的雌性和雄性大鼠表现出比D /成人大鼠的抑郁状行为的降低。此外，D /雌性大鼠在两龄龄群中表现出比雄性大鼠的抗强迫性行为降低。我们得出结论，该年龄没有对吗啡戒断的持续时间和整体依赖严重程度没有影响。虽然，女性在女性中取出的持续时间比雄性大鼠较低。我们的结果表明了吗啡戒断的持续时间和对吗啡的心理依赖表达的年龄差异的性别差异。因此，治疗策略对于身体和心理维度的依赖性个体可能是不同的。

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