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首页> 外文期刊>Philosophical Transactions of the Royal Society of London, Series B. Biological Sciences >Sex-specific effects of mitochondrial haplotype on metabolic rate in Drosophila melanogaster support predictions of the Mother's Curse hypothesis
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Sex-specific effects of mitochondrial haplotype on metabolic rate in Drosophila melanogaster support predictions of the Mother's Curse hypothesis

机译：线粒体单倍型对果蝇的代谢率的性别特异性效应母亲诅咒假设的支持预测

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Evolutionary theory proposes that maternal inheritance of mitochondria will facilitate the accumulation of mitochondrial DNA (mtDNA) mutations that are harmful to males but benign or beneficial to females. Furthermore, mtDNA haplotypes sampled from across a given species distribution are expected to differ in the number and identity of these 'male-harming' mutations they accumulate. Consequently, it is predicted that the genetic variation which delineates distinct mtDNA haplotypes of a given species should confer larger phenotypic effects on males than females (reflecting mtDNA mutations that are male-harming, but female-benign), or sexually antagonistic effects (reflecting mutations that are male-harming, but female-benefitting). These predictions have received support from recent work examining mitochondrial haplotypic effects on adult life-history traits in Drosophila melanogaster. Here, we explore whether similar signatures of male-bias or sexual antagonism extend to a key physiological trait-metabolic rate. We measured the effects of mitochondrial haplotypes on the amount of carbon dioxide produced by individual flies, controlling for mass and activity, across 13 strains of D. melanogaster that differed only in their mtDNA haplotype. The effects of mtDNA haplotype on metabolic rate were larger in males than females. Furthermore, we observed a negative intersexual correlation across the haplotypes for metabolic rate. Finally, we uncovered a male-specific negative correlation, across haplotypes, between metabolic rate and longevity. These results are consistent with the hypothesis that maternal mitochondrial inheritance has led to the accumulation of a sex-specific genetic load within the mitochondrial genome, which affects metabolic rate and that may have consequences for the evolution of sex differences in life history. This article is part of the theme issue 'Linking the mitochondrial genotype to phenotype: a complex endeavour'.
机译：进化理论提出的是线粒体的母体遗传将促进对男性有害但良性或有益于女性的线粒体DNA（MTDNA）突变的累积。此外，预期从给定物种分布中取样的MTDNA单倍型在它们积累的这些“男性伤害”突变的数量和身份中有所不同。因此，据预测，划清了给定物质的不同MTDNA单倍型的遗传变异应赋予男性的较大表型对雌性（反射MTDNA突变，所述MTDNA突变是雄性伤害，但女性良性）或性拮抗作用（反射突变这是伤害，而是女性受益。这些预测已经获得了最近的工作检查对果蝇Melanogaster的成人生命历史特征的影响力检查的支持。在这里，我们探讨了男性偏见或性拮抗作用的类似签名延伸到关键的生理性质 - 代谢率。我们测量了线粒体单倍型对各个苍蝇产生的二氧化碳量的影响，控制质量和活性的二氧化碳，其D. melanogaster的13个菌株仅在其MTDNA单倍型中不同。 MTDNA单倍型对男性的代谢率的影响比女性更大。此外，我们观察到单倍型以进行代谢率的负面差异相关性。最后，我们在代谢率和长寿之间发现了跨单倍型的男性特异性负相关性。这些结果与母体线粒体遗传引起的假设导致线粒体基因组内的性别特异性遗传载荷的积累，这影响了代谢率并且可能对生活历史中性别差异的演变产生后果。本文是主题问题的一部分“将线粒体基因型与表型联系起来：复杂的努力”。

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