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首页> 外文期刊>Philosophical Transactions of the Royal Society of London, Series B. Biological Sciences >Does epigenetic 'memory' of early-life stress predispose to chronic pain in later life? A potential role for the stress regulator FKBP5
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Does epigenetic 'memory' of early-life stress predispose to chronic pain in later life? A potential role for the stress regulator FKBP5

机译：表观遗传学'记忆'的早期压力会倾向于后期生命中的慢性疼痛吗？ 压力调节器FKBP5的潜在作用

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摘要

Animal behaviours are affected not only by inherited genes but also by environmental experiences. For example, in both rats and humans, stressful early-life events such as being reared by an inattentive mother can leave a lasting trace and affect later stress response in adult life. This is owing to a chemical trace left on the chromatin attributed to so-called epigenetic mechanisms. Such an epigenetic trace often has consequences, sometimes long-lasting, on the functioning of our genes, thereby allowing individuals to rapidly adapt to a new environment. One gene under such epigenetic control is FKBP5, the gene that encodes the protein FKPB51, a crucial regulator of the stress axis and a significant driver of chronic pain states. In this article, we will discuss the possibility that exposure to stress could drive the susceptibly to chronic pain via epigenetic modifications of genes within the stress axis such as FKBP5. The possibility that such modifications, and therefore, the susceptibility to chronic pain, could be transmitted across generations in mammals and whether such mechanisms may be evolutionarily conserved across phyla will also be debated.
机译：动物行为不仅受到遗传基因而且受到环境经验的影响。例如，在大鼠和人类中，压力的早期生命事件，如非专心的母亲饲养，可以留下持久的痕迹并影响成年生命中的后期压力反应。这是由于染色体留在染色体上的化学痕迹，归因于所谓的表观遗传机制。这种表观遗传痕迹通常具有后果，有时是长期持久的，因为我们基因的运作，从而允许个体快速适应新环境。在这种表观遗传对照下的一种基因是FKBP5，该基因编码蛋白质FKPB51，应力轴的关键调节剂和慢性疼痛状态的重要驾驶员。在本文中，我们将讨论暴露于压力的可能性可以通过应力轴内的基因的表观遗传修饰来驱动敏感性慢性疼痛，例如FKBP5。这种修饰的可能性，以及对慢性疼痛的易感性，可以跨越哺乳动物的几代传播，并且这些机制是否可以在培养基上被淘汰。

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