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首页> 外文期刊>Philosophical Transactions of the Royal Society of London, Series B. Biological Sciences >Early in life effects and heredity: reconciling neo-Darwinism with neo-Lamarckism under the banner of the inclusive evolutionary synthesis
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Early in life effects and heredity: reconciling neo-Darwinism with neo-Lamarckism under the banner of the inclusive evolutionary synthesis

机译：在生命影响和遗传的早期：在包容性进化合成的横幅下，调和新达尔文主义与新拉马里克

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摘要

Recent discoveries show that early in life effects often have long-lasting influences, sometimes even spanning several generations. Such intergenerational effects of early life events appear not easily reconcilable with strict genetic inheritance. However, an integrative evolutionary medicine of early life effects needs a sound view of inheritance in development and evolution. Here, we show how to articulate the gene-centred and non-gene-centred visions of inheritance. We first recall the coexistence of two gene concepts in scientific discussions, a statistical one (focused on patterns of parent-offspring resemblance, and implicitly including non-DNA-sequence-based resemblance), and a molecular one (based on the DNA sequence). We then show how all the different mechanisms of inheritance recently discovered can be integrated into an inclusive theory of evolution where different mechanisms would enable adaptation to changing environments at different timescales. One surprising consequence of this integrative vision of inheritance is that early in life effects start much earlier than fertilization.
机译：最近的发现表明，在生命影响的早期往往具有持久的影响，有时甚至跨越几代人。这种早期生命事件的代际影响似乎与严格的遗传遗传不容易和解。然而，早期生命效果的综合进化医学需要对发展和进化的遗传来说是一种声音。在这里，我们展示了如何阐明以基因为中心的基因和非基因为中心的遗传愿景。我们首先在科学讨论中召回两种基因概念的共存，统计学概念（专注于母体后代相似的模式，隐含地包括非DNA序列的相似性）和分子一（基于DNA序列） 。然后，我们展示了最近发现的所有不同继承机制如何集成到包含的不同机制将能够适应不同时间尺度的改变环境。这种综合遗传态度的一个令人惊讶的结果是，生命影响的早期早期比受精更早。

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