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首页> 外文期刊>Philosophical Transactions of the Royal Society of London, Series B. Biological Sciences >Cilia in the developing zebrafish ear
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Cilia in the developing zebrafish ear

机译：纤毛在开发的斑马鱼耳中

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摘要

The inner ear, which mediates the senses of hearing and balance, derives from a simple ectodermal vesicle in the vertebrate embryo. In the zebrafish, the otic placode and vesicle express a whole suite of genes required for ciliogenesis and ciliary motility. Every cell of the otic epithelium is ciliated at early stages; at least three different ciliary subtypes can be distinguished on the basis of length, motility, genetic requirements and function. In the early otic vesicle, most cilia are short and immotile. Long, immotile kinocilia on the first sensory hair cells tether the otoliths, biomineralized aggregates of calcium carbonate and protein. Small numbers of motile cilia at the poles of the otic vesicle contribute to the accuracy of otolith tethering, but neither the presence of cilia nor ciliary motility is absolutely required for this process. Instead, otolith tethering is dependent on the presence of hair cells and the function of the glycoprotein Otogelin. Otic cilia or ciliary proteins also mediate sensitivity to ototoxins and coordinate responses to extracellular signals. Other studies are beginning to unravel the role of ciliary proteins in cellular compartments other than the kinocilium, where they are important for the integrity and survival of the sensory hair cell. This article is part of the Theo Murphy meeting issue 'Unity and diversity of cilia in locomotion and transport'.
机译：内耳，介导听觉和平衡的感觉，源于脊椎动物胚胎中的一个简单的外胚层囊泡。在斑马鱼中，耳络垫和囊泡表达了纤毛生成和纤毛运动所需的整个基因。在早期阶段依赖于耳蜗上皮的每个细胞;至少三种不同的纤毛亚型可以基于长度，运动，遗传要求和功能来区分。在早期的耳囊中，大多数纤毛都是短暂的和免疫粘液。长，Immotile Kinocilia在第一感觉毛细胞上系右右侧，碳酸钙和蛋白质的生物抗体聚集体。在耳囊的极点的少量运动纤毛有助于欧替尔·彼得宁的准确性，但既不是纤毛的存在，也没有绝对需要这种过程。相反，偏醇鞘依赖性依赖于毛细胞的存在和糖蛋白otgelin的功能。 ONTic Cilia或睫状体蛋白还介导对耳毒素的敏感性，并对细胞外信号坐标响应。其他研究开始解开睫状蛋白在除磷酸盐之外的细胞室中的睫状蛋白的作用，其中它们对于感官毛细胞的完整性和存活是重要的。本文是Theo Murphy会议问题的一部分，在机动和运输中智利的慈善团结和多样性。

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