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首页> 外文期刊>Philosophical Transactions of the Royal Society of London, Series B. Biological Sciences >Epithelial-mesenchymal plasticity: emerging parallels between tissue morphogenesis and cancer metastasis
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Epithelial-mesenchymal plasticity: emerging parallels between tissue morphogenesis and cancer metastasis

机译：上皮 - 间充质塑性：组织形态发生与癌症转移之间的新出现相似之处

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摘要

Many cells possess epithelial-mesenchymal plasticity (EMP), which allows them to shift reversibly between adherent, static and more detached, migratory states. These changes in cell behaviour are driven by the programmes of epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET), both of which play vital roles during normal development and tissue homeostasis. However, the aberrant activation of these processes can also drive distinct stages of cancer progression, including tumour invasiveness, cell dissemination and metastatic colonization and outgrowth. This review examines emerging common themes underlying EMP during tissue morphogenesis and malignant progression, such as the context dependence of EMT transcription factors, a central role for partial EMTs and the nonlinear relationship between EMT and MET. This article is part of a discussion meeting issue 'Contemporary morphogenesis'.
机译：许多细胞具有上皮 - 间充质塑性（EMP），其允许它们可逆地在粘附，静态和更脱离的迁移状态之间转变。 细胞行为的这些变化由上皮 - 间充质转换（EMT）和间充质 - 上皮转换（Met）的程序驱动，这两者在正常发育和组织稳态期间起到重要作用。 然而，这些方法的异常活化也可以推动癌症进展的不同阶段，包括肿瘤侵袭性，细胞传播和转移性定植和产物。 本综述审查了在组织形态发生和恶性进展期间EMP潜在的常见主题，例如EMT转录因子的上下文依赖性，部分EMT和EMT与EMT之间的非线性关系的核心作用。 本文是讨论会议问题“当代形态发生”的一部分。

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