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首页> 外文期刊>BJU international >Prognostic impact of lymphovascular invasion in radical prostatectomy specimens.
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Prognostic impact of lymphovascular invasion in radical prostatectomy specimens.

机译：前列腺癌根治术标本中淋巴管浸润的预后影响。

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OBJECTIVE: To estimate the prognostic value of lymphovascular invasion (LVI) in patients with node-negative prostate cancer treated by radical prostatectomy (RP). PATIENTS AND METHODS: In all, 412 patients with prostatic adenocarcinoma who had RP and pN0 status were analysed for all established standard pathological factors and LVI. The influence of these pathological findings on biochemical failure was evaluated by multivariate analysis with the Cox model. The mean (range) follow-up was 52.5 (10-116) months. RESULTS: LVI was identified in 42 patients (10.2%) and significantly associated with a high preoperative prostate-specific antigen (PSA) level, a high PSA density, high percentage of positive biopsy cores, high Gleason score, and seminal vesicle invasion. Of the 42 patients with LVI, 33 (79%) had a Gleason score of > or = 7 and 27 (64%) had pathological stage pT3. The 5-year biochemical-free survival was 87.3% for patients with no LVI and 38.3% with LVI on the RP specimen (P < 0.001). By multivariate analysis, LVI and Gleason score were independent predictors of biochemical failure. CONCLUSION: These results show that in addition to the Gleason score, only LVI is strongly correlated with biochemical failure after RP. These findings support the routine evaluation of LVI status in RP specimens and provide the option for its incorporation into nomograms predictive of oncological outcome.
机译：目的：评估经淋巴结清扫术（RP）治疗淋巴结阴性前列腺癌患者的淋巴管浸润（LVI）的预后价值。患者与方法：总共分析了412例具有RP和pN0状况的前列腺腺癌患者的所有既定标准病理因素和LVI。这些病理结果对生化衰竭的影响通过Cox模型进行多变量分析来评估。平均（范围）随访为52.5（10-116）个月。结果：在42例患者中发现了LVI（10.2％），并且与术前前列腺特异性抗原（PSA）水平高，PSA密度高，活检核心阳性率高，格里森评分高和精囊侵犯密切相关。在42例LVI患者中，有33例（79％）的Gleason评分≥7，而27例（64％）的病理分期为pT3。在RP标本上无LVI的患者的5年无生化生存率为87.3％，有LVI的患者为38.3％（P <0.001）。通过多变量分析，LVI和格里森评分是生化失败的独立预测因子。结论：这些结果表明，除了格里森评分外，只有LVI与RP后的生化衰竭密切相关。这些发现支持常规评估RP标本中LVI的状态，并为将其纳入预测肿瘤学结果的诺模图提供了选择。

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