• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pesticide Research Journal >Effect of Monocrotophos on Pubertal Development, Reproductive and Thyroid Axis in Male Wistar Rats
【24h】

Effect of Monocrotophos on Pubertal Development, Reproductive and Thyroid Axis in Male Wistar Rats

机译：猴手对幼稚病大鼠青春期发育，繁殖和甲状腺轴的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The male pubertal assay is a Tier I screening assay to detect potential endocrine active chemicals (EAC) acting through a variety of steroid hormone and thyroid hormone receptor-mediated and non-receptor-mediated mechanisms. This study reports the effect of monocrotophos technical (MCT) on pubertal development and thyroid function in the intact juvenile/peripubertal male rats. Water (RO) was administered in Group 1 animals (negative control group). 1-Chloro-2-nitrobenzene (CNB) was administered to Group 2 (positive control group) animals at 100 mg kg~(-1). MCT was administered to Group 3, Group 4, and Group 5 animals at 0.1,1.0 and 2.0 mg kg~(-1), respectively. On post netal day 53, blood was collected for clinical pathology and hormone analysis. After sacrifice through decapitation, necropsy was performed and organs were collected. Shivering was observed for 3-4 h in all the rats treated with MCT at 1.0 and 2.0 mg kg~(-1). Significant reduction in body weight, body weight gain and feed consumption was observed in the rats treated with CNB and MCT (2.0 mg kg~(-1)). Body weight at complete preputial separation was significantly decreased in rats treated with MCT (2.0 mg kg~(-1)). Significant increase in alanine amino transferase (ALT), phosphorus, blood urea nitrogen (BUN), and urea was observed in the animals treated with MCT at 2.0 mg kg~(-1). Significant decrease in serum testosterone was observed in the animals treated with MCT (2.0 mg kg~(-1)). Reduction in body weight or serum testosterone level and marginal delay in puberty in MCT (2.0 mg kg~(-1)) treated group could be due to systemic toxicity. It was concluded that MCT is not a thyroid toxicant based on serum thyroid hormone level and microscopic examination.
机译：雄性青春期测定是一种层，用于检测通过各种类固醇激素和甲状腺激素受体介导的潜在内分泌活性化学品（EAC）的筛选试验，以探测通过各种类固醇激素和甲状腺激素受体介导和非受体介导的机制。本研究报告了孟霉素技术（MCT）对完整幼年/植物雄性大鼠的青春期发育和甲状腺功能的影响。在1组动物（阴性对照组）中施用水（RO）。在100mg kg〜（-1）下给予1-氯-2-硝基苯（CNB）至第2组（阳性对照组）动物。将MCT施用于第3组，第4组和第5类动物，分别为0.1,1.0和2.0mg kg〜（-1）。在核节第53天后，收集血液用于临床病理和激素分析。在通过斩首牺牲后，进行尸检，收集器官。在1.0和2.0mg kg〜（-1）的MCT处理的所有大鼠中，观察到颤抖3-4小时。在用CNB和MCT处理的大鼠中观察到体重，体重增加和饲料消耗的显着降低（2.0mg kg〜（-1））。用MCT处理的大鼠完全预分离的体重显着降低（2.0mg kg〜（-1））。在用MCT在2.0mg kg〜（-1）处理的动物中，观察到丙氨酸氨基转移酶（ALT），磷，血尿尿素氮（BUN）和尿素的显着增加。在用MCT处理的动物中观察到血清睾酮的显着降低（2.0mg kg〜（-1））。在MCT中减少体重或血清睾酮水平和青春期的边缘延迟（2.0mg kg〜（-1））治疗组可能是由于全身毒性。结果表明，MCT不是基于血清甲状腺激素水平和微观检查的甲状腺毒性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号