• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pesticide Research Journal >Expression of TLR-9 and IL-1β following Concomitant Exposure to Imidacloprid and Endotoxin
【24h】

Expression of TLR-9 and IL-1β following Concomitant Exposure to Imidacloprid and Endotoxin

机译：伴随含吡虫啉和内毒素的TLR-9和IL-1β的表达

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Imidacloprid is used for crop protection and flea control. Its unintentional impacts on various target organs have been described and the possible toxicological interaction with imidacloprid and endotoxin is reported in this study. Male Swiss albino mice were administered imidacloprid orally at 1/20~(th) of LD_(50) dissolved in corn oil for 30 d. Five animals from each group were challenged with lipopolysaccharide (LPS) or normal saline solution (NSS) at 80 ug mouse~(-1) administered intranasally. There was no change (p<0.05) in the expression of toll like receptor 9 (TLR-9) and interleukin-1-beta (IL-1β) both at mRNA and protein levels in lungs following exposure to imidacloprid alone or in combination with lipopolysaccharides. But, a significant decrease in serum concentration of IL-1β protein levels and an increase in serum TLR-9 levels between control and imidacloprid treated animals was observed. The data showed that imidacloprid alone or in combination with LPS altered the expression of TLR-9 and IL-1β in peripheral blood suggesting its immunomodulatory potential.
机译：ImidaCloprid用于作物保护和跳蚤控制。已经描述了对各种靶器官的无意产生影响，并且本研究报告了与吡虫啉和内毒素可能的毒理学相互作用。在溶解在玉米油中的1/20〜（Th）溶解于30天的LD_（50）的1/20〜（Th）施用甲状腺醇啉代吡啶啉代吡啶啉代比例。来自每组的五只动物在鼻内给药的80μg小鼠〜（-1）时用脂多糖（LPS）或正常的盐水溶液（NSS）攻击。在暴露于胰岛素单独或结合的肺泡之后，在肺部mRNA和蛋白质水平中，在mRNA和蛋白质水平上，没有变化（p <0.05）。脂多糖。但是，观察到IL-1β蛋白水平血清浓度的显着降低以及对照和吡虫啉的动物之间的血清TLR-9水平的增加。该数据显示单独或与LPS组合的吡虫啉改变了外周血中TLR-9和IL-1β的表达，表明其免疫调节潜力。

著录项

  • 来源
    《Pesticide Research Journal》 |2017年第2期|共8页
  • 作者

    Arif Ahmad Pandit; Chandra S Mukhopadhyay; Ramneek;

  • 作者单位

    School of Animal Biotechnology Guru Angad Dev Veterinary and Animal Sciences University Ludhiana 141 004 Punjab India;

    School of Animal Biotechnology Guru Angad Dev Veterinary and Animal Sciences University Ludhiana 141 004 Punjab India;

    School of Animal Biotechnology Guru Angad Dev Veterinary and Animal Sciences University Ludhiana 141 004 Punjab India;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 植物保护;
  • 关键词

    Imidacloprid; LPS; TLR-9; IL-1β;

    机译：Imidclaprid;LPS;TLR-9;IL-1β;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号