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首页> 外文期刊>BJU international >Genetic impact on prostate anatomical variability during ageing: role of CYP17, SRD5A2 and androgen receptor genes polymorphisms.
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Genetic impact on prostate anatomical variability during ageing: role of CYP17, SRD5A2 and androgen receptor genes polymorphisms.

机译：衰老过程中对前列腺解剖变异的遗传影响：CYP17，SRD5A2和雄激素受体基因多态性的作用。

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OBJECTIVES To investigate the role of genetic determinism on individual variability in age-related prostate changes, as defining 'normal' anatomy in prostate gland ageing is a challenge because the variability of changes in prostate morphology increases with age. MATERIALS AND METHODS We assessed the influence of androgen- and oestrogen-regulating genetic polymorphisms on age-related weight and stromal-ratio changes in the prostate, using an anatomical, autopsy-based study. We quantified weight and glandular/stromal ratio in 85 autopsy prostates from men aged > 50 years. We genotyped allelic variants of androgen-regulating genes [androgen receptor (CAG repeats) and type II 5-alpha reductase (TA repeat and V89L)] and an oestrogen-regulating gene (A1/A2 variants of the 17alpha-hydroxylase (CYP17)). RESULTS There was a fair negative correlation between prostate weight and the number of CAG repeats (r = -0.32, P = 0.003); the group with /= 20 group (P = 0.015). The stromal ratio was higher in the group with 20-23 CAG repeats (P = 0.02) and in the A2A2 group of the CYP17 polymorphism (P = 0.016) compared with the other groups mixed together. CONCLUSION A low number of CAG repeats is associated with higher prostate weights. The A2A2 genotype of CYP17 is associated with a higher stromal ratio.
机译：目的探讨遗传决定论在与年龄相关的前列腺变化中个体变异性中的作用，因为定义前列腺形态变化的变异性随年龄而增加，因此定义前列腺腺衰老的“正常”解剖结构是一项挑战。材料和方法我们使用基于解剖学的尸检研究，评估了雄激素和雌激素调节基因多态性对与年龄相关的体重和前列腺基质比率变化的影响。我们对年龄大于50岁的85位尸检前列腺中的体重和腺/基质比进行了量化。我们对雄激素调节基因的等位基因变体[雄激素受体（CAG重复）和II型5-α还原酶（TA重复和V89L）]和一个雌激素调节基因（17α-羟化酶的A1 / A2变体（CYP17））进行基因分型。结果前列腺重量与CAG重复次数之间存在相当的负相关（r = -0.32，P = 0.003）; / = 20组的前列腺重（P = 0.015）。与混合在一起的其他组相比，具有20-23个CAG重复的组（P = 0.02）和CYP17多态性的A2A2组（P = 0.016）的基质比率更高。结论CAG重复次数少与前列腺重量增加有关。 CYP17的A2A2基因型与较高的基质比率有关。

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