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首页> 外文期刊>Pharmacological research: The official journal of The Italian Pharmacological Society >Kinin B1 receptor: A target for neuroinflammation in hypertension
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Kinin B1 receptor: A target for neuroinflammation in hypertension

机译：Kinin B1受体：高血压神经炎症的靶标

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摘要

Kinins are a family of oligopeptides of the kallikrein-kinin system that act as potent vasoactive hormones and inflammatory mediators. The bioactive kinins mainly consist of bradykinin and kallidin, and their metabolites des-Arg(9)-bradykinin and des-Arg(10)-kallidin. Physiological effects of kinins are mediated by activation of highly selective G-protein coupled kinin B1 and B2 receptors. Growing evidence suggests that B1 receptor activation mediates diverse physiological and pathological features of cardiovascular diseases. However, studies are limited regarding the impact of B1 receptor mediated neuroinflammation on the development of hypertension and other cardiovascular diseases. Given the potential role for B1 receptor activation in immune cell infiltration, microglia activation, and cytokine production within the central nervous system, B1 receptor mediated signaling cascades might result in elevated neuroinflammation. In this review, we will discuss the potential pro-inflammatory role of B1 receptor activation in hypertension. A better understanding of B1 receptor inflammatory signaling may lead to the development of therapeutics that target B1 receptors to treat neurogenic hypertension.
机译：Kinins是Kallikrein-kinin系统的寡肽系列，其充当有效的血管活性激素和炎症介质。生物活性酸主要由Bradykinin和Kallidin组成，它们的代谢物Des-Arg（9）-Bradykinin和Des-Arg（10）-Kallidin。通过高选择性G-蛋白偶联的Kinin B1和B2受体激活磷锡的生理效果。日益增长的证据表明B1受体激活介导心血管疾病的不同生理和病理特征。然而，关于B1受体介导的神经引发对高血压和其他心血管疾病的影响的影响有限。鉴于B1受体激活在免疫细胞浸润中的潜在作用，中枢神经系统内的小胶质细胞活化和细胞因子产生，B1受体介导的信号级联可能导致神经引发升高。在本综述中，我们将讨论B1受体激活在高血压中的潜在炎症作用。更好地理解B1受体炎症信号传导可能导致靶向B1受体治疗神经源性高血压的治疗剂的发展。

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