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首页> 外文期刊>BJU international >The effects of tolterodine on bladder-filling sensations and perception thresholds to intravesical electrical stimulation: method and initial results.
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The effects of tolterodine on bladder-filling sensations and perception thresholds to intravesical electrical stimulation: method and initial results.

机译：托特罗定对膀胱内电刺激的膀胱充盈感和知觉阈值的影响：方法和初步结果。

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OBJECTIVES To study the effects of the antimuscarinic agent tolterodine on the perception thresholds to intravesical electrical stimulation (IES) and the effects of the drug on subjective bladder sensation during normal filling cystometry in healthy female volunteers. SUBJECTS AND METHODS In seven healthy women IES was applied at 2.5 Hz (pulse width 10 ms, protocol 1), 2.5 Hz (pulse width 0.2 ms, protocol 2), and 250 Hz (pulse width 0.2 ms, protocol 3). Sensory perception thresholds were obtained using electric currents in 0.5 mA steps. Afterwards the bladder was filled and the first bladder-filling sensation, first desire to void, strong desire to void and urge to void were recorded. The bladder was then emptied, the volume measured and subjects were checked for residual urine by ultrasonography. The subjects then received 4 mg of tolterodine and the entire protocol was repeated 2 h afterward. The perception thresholds for IES and bladder sensation levels obtained at baseline were compared statistically with the corresponding values after tolterodine. RESULTS Tolterodine significantly increased perception thresholds to IES for all three protocols (P = 0.027, 0.018 and 0.018, respectively). The drug had no effect on the filling levels for the corresponding bladder sensation. CONCLUSION Oral tolterodine significantly increased the perception threshold to IES in healthy women; there was no effect on subjective bladder sensations during cystometry.
机译：目的研究健康女性志愿者在正常充盈性膀胱测压法中抗毒蕈碱剂托特罗定对膀胱内电刺激（IES）感知阈值的影响以及药物对主观膀胱感觉的影响。研究对象和方法在七名健康女性中，以2.5 Hz（脉冲宽度10 ms，协议1），2.5 Hz（脉冲宽度0.2 ms，协议2）和250 Hz（脉冲宽度0.2 ms，协议3）应用IES。使用电流以0.5 mA的步长获得感官知觉阈值。之后，膀胱被充满，并且记录了第一膀胱填充感觉，首先的排尿欲望，强烈的排尿欲望和敦促排尿的欲望。然后排空膀胱，测量体积并通过超声检查检查对象是否残留尿液。然后受试者接受4 mg托特罗定，之后2 h重复整个实验方案。将IES的知觉阈值和基线时获得的膀胱感觉水平与托特罗定治疗后的相应值进行统计学比较。结果对于所有三种方案，托特罗定显着提高了IES的感知阈值（分别为P = 0.027、0.018和0.018）。该药物对相应的膀胱感觉的充盈水平没有影响。结论口服托特罗定可显着提高健康女性对IES的感知阈值。在膀胱测压期间对主观膀胱感觉没有影响。

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