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首页> 外文期刊>BJU international >Urological malignancy after renal transplantation.
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Urological malignancy after renal transplantation.

机译：肾移植后泌尿系统恶性肿瘤。

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摘要

Immunosuppression in solid-organ recipients is associated with a greater risk of de novo malignancy after transplantation; herein we report the UK transplant registry (UKTR) database of urological cancer after renal transplantation in the UK transplant population. From September 1999 to January 2006 there were 10 847 kidney recipients with at least one period of follow-up reported after a kidney transplant (mean age at transplantation 42.4 years, sd 15.5; 6685 male, 61.6%, and 4162 female, 38.3%). The recipients represent a homogenous group who received different immunosuppression regimens. Skin cancer was excluded from the study. Unfortunately, the UKTR does not collect information about the presence or absence of cancer, either at registration onto the transplant waiting list or at transplantation. In all, 214 (1.9%) patients were reported to have a subsequent urological malignancy diagnosed among the 10 847 recipients. The UKTR was used to identify patients who developed urological malignancies after renal transplantation, which is a challenging event after solid-organ transplantation. Regular surveillance to diagnose early occurrence and adjustment of immunosuppression might be beneficial. In the presence of metastatic disease, chemotherapy treatment with adjustment or cessation of immunosuppressive therapy is required.
机译：实体器官接受者的免疫抑制与移植后从新发生恶性肿瘤的风险较高有关。本文中，我们报告了英国移植人群中肾脏移植后泌尿系统癌症的UK移植注册表（UKTR）数据库。从1999年9月到2006年1月，有10 847名肾移植受者接受了肾移植后至少一个随访期的报告（移植时的平均年龄42.4岁，标准差15.5;男性6685，男性61.6％，女性4162，女性38.3％）。 。接受者代表接受不同免疫抑制方案的同质组。该研究排除了皮肤癌。不幸的是，无论是在移植等待名单上还是移植时，UKTR都不会收集有关癌症存在与否的信息。据报告，在10 847名接受者中，共有214名（1.9％）患者被诊断出随后的泌尿系统恶性肿瘤。 UKTR用于鉴定肾移植后发生泌尿系统恶性肿瘤的患者，这是实体器官移植后的一项具有挑战性的事件。定期监测以早期诊断和调整免疫抑制可能是有益的。在存在转移性疾病的情况下，需要调整或停止免疫抑制疗法的化学疗法治疗。

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