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The development of structural x-ray crystallography

机译:结构X射线晶体学的发展

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摘要

From its birth in 1912, when only the simplest structures could be solved, x-ray structural crystallography is now able to solve macromolecular structures containing many thousands of independent non-hydrogen atoms. This progress has depended on, and been driven by, great technical advances in the development of powerful synchrotron x-ray sources, advanced automated equipment for the collection and storage of large data sets and powerful computers to deal with everything from data processing to running programmes employing complex algorithms for the automatic solution of structures. The sheer number of developments in the subject over the past century makes it impossible for this review to be exhaustive, but it will describe some major developments that will enable the reader to understand how the subject has grown from its humble beginnings to what it is today.
机译:从1912年出生,当只有最简单的结构可以解决时,X射线结构晶体学现在能够解决含有数千个独立的非氢原子的大分子结构。 这一进展依赖于,强大的同步X射线源,高级自动化设备的发展和存储的大型数据集和功能强大的计算机,以处理从数据处理到运行程序的所有内容的高级自动化设备 采用复杂算法进行结构的自动解决方案。 在过去的世纪受试者的发展众多的发展使得这综述不可能详尽无遗,但它将描述一些重要的发展,使读者能够了解主题如何从其卑微的开始到今天的东西 。

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