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Addition of internal electrodes is beneficial for focused bioimpedance measurements in the lung

机译:内部电极的添加是有益于肺中的聚焦生物阻抗测量

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Objective: Bioimpedance measurements such as bioimpedance spectroscopy (BIS) or electrical impedance tomography (EIT) are used in many biomedical applications. While BIS measures and analyzes the impedance in a frequency range at constant electrode positions, EIT aims to reconstruct images of the conductivity distribution from multiple measurements at different electrode positions. Our aim is to add spatial information to tetrapolar BIS measurements by using electrode positions that focus measurements on desired regions of interest. In this paper, we aim to investigate, whether internal electrodes that can be integrated into breathing or gastroesophageal tubes, can improve the local sensitivity of bioimpedance spectroscopy measurements. Approach: We present the results of a simulation study, in which we investigated more than 4 M different electrode configurations on their ability to monitor specific regions of interest (ROI) in the lung. Based on the sensitivity, which describes the impact of a conductivity change on the measured impedance, we define three main criteria which we use to evaluate our simulation results: the selectivity S, which describes the impact of a conductivity change inside the region of interest compared to a conductivity change outside the ROI; the homogeneity H, which describes the distribution of the sensitivity inside the ROI; and the absolute impedance contribution ratio Iabs, which describes the contribution of the ROI to the measured impedance. Main results: Depending on the region of interest, electrode configurations using internal electrodes are between 9.8 % and 90 % better with respect to these criteria than configurations using external electrodes only. Significance: The combination of internal and external electrodes improves the focusing ability of tetrapolar impedance measurements on specific lung regions, which may be especially beneficial for lung monitoring in intensive care.
机译:目的:许多生物医学应用中使用等生物阻抗测量等生物阻抗光谱(BIS)或电阻抗断层扫描(EIT)。虽然BIS测量并在恒定电极位置处的频率范围内的阻抗,但EIT旨在重建从不同电极位置的多测量的电导率分布的图像。我们的目的是通过使用电极位置对焦点对所需感兴趣区域的电极位置进行焦点的位置来增加空间信息。在本文中,我们的目标是研究,是否可以集成到呼吸或胃食管管中的内部电极可以提高生物阻抗光谱测量的局部敏感性。方法:我们介绍了模拟研究的结果,其中我们研究了超过4米的不同电极配置,以便他们监测肺中的特定感兴趣区域(ROI)的能力。基于描述电导率变化对测量阻抗的影响的灵敏度,我们定义了三个我们用于评估我们的仿真结果的主要标准:选择性S,它描述了相比之下的感兴趣区域内的电导率变化的影响在ROI外的电导率变化;均匀性H,描述了ROI内敏感性的分布;和绝对阻抗贡献比IABS,其描述了投资回报率对测量阻抗的贡献。主要结果:根据感兴趣区域,相对于使用外部电极的配置,使用内部电极的电极配置比使用外部电极的配置更好地介于9.8%和90%之间。意义:内部和外部电极的组合改善了特异性肺区四极阻抗测量的聚焦能力,这对重症监护肺监测可能特别有益。

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