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首页> 外文期刊>Photochemical & photobiological sciences: the official journal of the European Photochemistry Association and the European Society for Photobiology >The SOS Chromotest applied for screening plant antigenotoxic agents against ultraviolet radiation
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The SOS Chromotest applied for screening plant antigenotoxic agents against ultraviolet radiation

机译：SOS Chromotest应用于筛选植物抗抗菌剂免受紫外线辐射

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摘要

In this work, we investigated the usefulness of the SOS Chromotest for screening plant antigenotoxic agents against ultraviolet radiation (UV). Fifty Colombian plant extracts obtained by supercritical fluid (CO2) extraction, twelve plant extract constituents (apigenin, carvacrol, beta-caryophyllene, 1,8-cineole, citral, p-cymene, geraniol, naringenin, pinocembrin, quercetin, squalene, and thymol) and five standard antioxidant and/or photoprotective agents (curcumin, epigallocatechin gallate, resveratrol, a-tocopherol, and Trolox (R)) were evaluated for their genotoxicity and antigenotoxicity against UV using the SOS Chromotest. None of the plant extracts, constituents or agents were genotoxic in the SOS Chromotest at tested concentrations. Based on the minimal extract concentration that significantly inhibited UV-geno-toxicity (CIG), five plant extracts were antigenotoxic against UV as follows: Baccharis nitida (16 mu g mL(-1)) = Solanum crotonifolium (16 mu g mL(-1)) > Hyptis suaveolens (31 mu g mL(-1)) = Persea caerulea (31 mu g mL(-1)) > Lippia origanoides (62 mu g mL(-1)). Based on CIG values, the flavonoid compounds showed the highest antigenotoxic potential as follows: apigenin (7 mu M) > pinocembrin (15 mu M) > quercetin (26 mu M) > naringenin (38 mu M) > epigallocatechin gallate (108 mu M) > resveratrol (642 mu M). UV-genotoxicity inhibition with epi-gallocatechin gallate, naringenin and resveratrol was related to its capability for inhibiting protein synthesis. A correlation analysis between compound antigenotoxicity estimates and antioxidant activity evaluated by the oxygen radical absorbance capacity (ORAC) assay showed that these activities were not related. The usefulness of the SOS Chromotest for bioprospecting of plant antigenotoxic agents against UV was discussed.
机译：在这项工作中，我们研究了SOS Chromotest对紫外线辐射（UV）筛选植物抗原毒性剂的有用性。通过超临界流体（CO2）萃取，12种植物提取物成分（Apigenin，Carvacrol，β-羧基，1,8- Cineole，Citral，P-Cyymene，Geraniol，Naringenin，Pinocembrin，槲皮素，Squalene和Thymol而获得的五十种植物提取物提取物）和使用SOS Chramotest的遗传毒性和抗原毒性评估五种标准抗氧化剂和/或光保护剂（姜黄素，epigallocaTechinganget，白藜芦醇，α-生育酚和Trolex（R））。在测试浓度下，植物提取物，成分或药剂中的遗传毒性是遗传毒性。基于显着抑制紫外线毒性（CIG）的最小提取物浓度，五种植物提取物对UV进行抗原毒性，如下：Baccharis Nitida（16μgml（-1））=茄属rotoNifolum（16μgml（ - 1））> Hyptis Suaveolens（31μgml（-1））= Persea Caerulea（31μgmml（-1））> lippia oriOnoides（62μgml（-1））。基于CIG值，黄酮类化合物显示出最高的抗原毒性潜力如下：Apigenin（7μm）>吡塞蛋白（15μm）>槲皮素（26μm）>芽孢酮（38 mu m）> Epigallocatechin gallate（108 mu m ）>白藜芦醇（642亩）。紫外线 - 基因毒性抑制与外延寄生虫，Naringenin和白藜芦醇与其抑制蛋白质合成的能力有关。通过氧自由基吸收能力（ORAC）测定评估的复合抗原毒性估计和抗氧化活性的相关分析表明这些活性无关。讨论了SOS Chrosotest对植物抗原毒性药物免受UV的生物掩模。

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