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首页> 外文期刊>Physiology & behavior >Neurobiological evidence for attention bias to food, emotional dysregulation, disinhibition and deficient somatosensory awareness in obesity with binge eating disorder
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Neurobiological evidence for attention bias to food, emotional dysregulation, disinhibition and deficient somatosensory awareness in obesity with binge eating disorder

机译：神经生物学证据，用于食物，情感失调，令人沮丧和患有狂犬病的肥胖症患者的患病症意识

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Abstract Objectives To refine the biobehavioral markers of binge eating disorder (BED). Methods We conducted fMRI brain scans using images of high energy processed food (HEPF), low energy unprocessed food (LEUF), or non-foods (NF) in 42 adults (obese with BED [obese -BED; n=13] and obese with no BED [obese non-BED; n=29]) selected via ads. Two blood oxygenated level dependent (BOLD) signal contrast maps were examined: food versus nonfood, and HEPF versus LEUF. In addition, score differences on the disinhibition scale were correlated with BOLD signals. Results food versus nonfood showed greater BOLD activity for BED in emotional, motivational and somatosensory brain areas: insula, anterior cingulate cortex (ACC), Brodmann areas (BA) 19 & 32, inferior parietal lobule (IPL), posterior cingulate cortex (PCC), and lingual, postcentral, middle temporal and cuneate gyri (p≤0.005; k≥88). HEPF versus LEUF showed greater BOLD activity for BED in inhibitory brain regions: BA 6, middle and superior frontal gyri (p Discussion Food images elicited neural activity indicating attention bias (cuneate & PCG), emotion dysregulation (BA 19 & 32), and disinhibition (MFG, BA6 & SFG) in obese with BED. These may help tailor a treatment for the obesity with BED phenotype. Highlights ? Obesity with BED (obese-BED) may differ from obesity with no BED (obese non-BED). ? The two groups were brain scanned with images of food and nonfood items. ? Disinhibition score and fMRI signal were correlated and compared between the groups. ? fMRI signal differed in emotional, motivational, somatosensory and inhibitory regions. ? The post-central gyrus predicted greater disinhibition.
机译：摘要目标优化狂犬病患者的生物侵蚀性标记（床）。方法采用高能量加工食品（HEPF），低能量未加工食品（Leuf）或42名成人的非食物（NF）进行FMRI脑扫描（肥胖的床[肥胖; N = 13]和肥胖没有床（肥胖的非床; n = 29]）通过广告选择。检查了两种血液含氧水平（粗体）信号对比图：食物与非食物和HEPF与Leuf。此外，不禁止尺度的分数差异与粗体信号相关。结果食物与非食物在情感，励磁和躯体感应脑区展示床上的大胆活动：Inslua，前刺铰接皮质（ACC），Brodmann地区（Ba）19＆32，劣质顶叶（IPL），后铰链皮质（PCC） ，语言，后中心，中间时，中间颞和粘合剂吉尔（P≤0.005;k≥88）。 HEPF与Leuf在抑制脑区床上展示了更大的大胆活动：BA 6，中间和高级寄生虫（P讨论食物图片引出神经活动，表明注意偏见（CUNEATE＆PCG），情感失调（BA 19＆32）和禁止（MFG，BA6＆SFG）在肥胖的床上。这些可能有助于用床表型来定制肥胖的治疗。亮点？床上肥胖（肥胖床）可能因肥胖而没有床（肥胖的床）。两组是用食物和非食物的图像扫描的大脑。禁止分数和FMRI信号相关并在组之间进行比较。禁止。

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