Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement

Matic Maja; Jongen Joost L. M.; Elens Laure; de Wildt Saskia N.; Tibboel Dick; Smitt Peter A. E. Sillevis; van Schaik Ron H. N.

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Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement

机译：晚期癌症疼痛：寻找与阿片类药物需求中的细胞性变异相关的遗传因素

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Aim: To assess association between genetic variants and opioid requirement in cancer patients. Materials & methods: A prospective observational trial of 243 advanced cancer patients with inadequate analgesia treated by the palliative care team was analyzed for ABCB1, ARRB2, COMT, GCH1, IL1RN, KCNJ6, OPRM1, RHBDF2, SCN9A and Stat6 polymorphisms. Results: For patients carrying OPRM1 118AG/GG and COMT 472GG (Val158Val) or these genotypes alone, a significant higher median percentage dose increase was observed (95.2% [32.8-345]) compared with OPRM1 118AA and COMT 472GA/AA (158Met allele carriers; 48.5% [0-98.8]; p = 0.0016). No associations were found with morphine equivalent dose after consultation palliative care team or ketamine use. Conclusion: Patients with the combined OPRM1 118AG/GG and COMT 472GG genotype required 50% higher dose increase for sufficient analgesia.

机译：目的：评估癌症患者遗传变体与阿片类药物需求之间的关联。材料和方法：分析了姑息治疗群体治疗243例高级癌症患者的前瞻性观察试验，对ABCB1，ARRB2，COMT，GCH1，IL1RN，KCNJ6，OPRM1，RHBDF2，SCN9A和STAT6多态性进行了分析。结果：对于携带OPRM1 118AG / GG和COMT 472GG（VAL158VAL）或这些基因型的患者，观察到显着的更高的中值百分比剂量增加（95.2％[32.8-345]）与OPRM1 118AA和COMT 472GA / AA（158MET等位基因载体; 48.5％[0-98.8]; p = 0.0016）。在咨询姑息治疗团队或氯胺酮使用后，无菌当量剂量没有发现任何相关剂量。结论：患者患者组合的OPRM1 118AG / GG和COMT 472GG基因型需要50％的剂量增加足够的镇痛。

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来源
《Pharmacogenomics》 |2017年第12期|共10页
作者
Matic Maja; Jongen Joost L. M.; Elens Laure; de Wildt Saskia N.; Tibboel Dick; Smitt Peter A. E. Sillevis; van Schaik Ron H. N.;
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作者单位

Univ Med Ctr Rotterdam Dept Clin Chem Erasmus MC Rotterdam Netherlands;

Univ Med Ctr Rotterdam Dept Neurol Erasmus MC Rotterdam Netherlands;

Catholic Univ Louvain Louvain Drug Res Inst Brussels Belgium;

Univ Med Ctr Rotterdam Sophia Childrens Hosp Dept Pediat Surg Erasmus MC Rotterdam Netherlands;

Univ Med Ctr Rotterdam Sophia Childrens Hosp Dept Pediat Surg Erasmus MC Rotterdam Netherlands;

Univ Med Ctr Rotterdam Dept Neurol Erasmus MC Rotterdam Netherlands;

Univ Med Ctr Rotterdam Dept Clin Chem Erasmus MC Rotterdam Netherlands;

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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
cancer; pain; pharmacogenetics;

机译：癌症;疼痛;药物发生;

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专利

1. Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement [J] . Matic Maja, Jongen Joost L. M., Elens Laure, Pharmacogenomics . 2017,第12期

机译：晚期癌症疼痛：寻找与阿片类药物需求中的细胞性变异相关的遗传因素
2. Factors predicting requirement of high-dose transdermal fentanyl in opioid switching from oral morphine or oxycodone in patients with cancer pain. [J] . Kanbayashi Y, Hosokawa T, Okamoto K, The clinical journal of pain . 2011,第8期

机译：预测癌症疼痛患者从口服吗啡或羟考酮类阿片类药物转换中需要大剂量透皮芬太尼的因素。
3. Single-Nucleotide Polymorphisms in TAOK3 Are Associated With High Opioid Requirement for Pain Management in Patients With Advanced Cancer Admitted to a Tertiary Palliative Care Unit [J] . Timothy Gutteridge, Mahalakshmi Kumaran, Sunita Ghosh, Journal of pain and symptom management. . 2018,第4期

机译：塔科氏菌的单核苷酸多态性与高级癌症患者患者疼痛管理的高阿片类药物需求相关
4. Attacking the Opioid Epidemic: Determining the Epistatic and Pleiotropic Genetic Architectures for Chronic Pain and Opioid Addiction [C] . Wayne Joubert, Deborah Weighill, David Kainer, International Conference for High Performance Computing, Networking, Storage and Analysis . 2018

机译：攻击阿片类药物流行：确定上位性和多发性遗传结构的慢性疼痛和阿片类药物成瘾
5. Association of Opioid Requirement and Cancer Pain with Survival in Advanced Non-Small Cell Lung Cancer [D] . Zylla, Dylan M. 2017

机译：阿片类药物需求和癌痛与晚期非小细胞肺癌生存率的关系
6. Association of opioid requirement and cancer pain with survival in advanced non-small cell lung cancer [O] . D. Zylla, M.A. Kuskowski, K. Gupta, -1

机译：阿片类药物需求和癌痛与晚期非小细胞肺癌生存率的关系
7. Single-Nucleotide Polymorphisms in TAOK3 Are Associated With High Opioid Requirement for Pain Management in Patients With Advanced Cancer Admitted to a Tertiary Palliative Care Unit [O] . Timothy Gutteridge, Mahalakshmi Kumaran, Sunita Ghosh, 2018

机译：塔科氏三核苷酸多态性与高级癌症患者疼痛管理的高阿片类药物要求有关，患有高等群体姑息治疗单位
8. Patterns and Correlates of Prescription Opioid Use in OEF/OIF Veterans with Chronic Non-Cancer Pain. [R] . Macey, T. A., Morasco, B. J., Duckart, J. P., 2011

机译：OEF / OIF退伍军人慢性非癌性疼痛中处方阿片类药物使用的模式和相关性。

Advanced cancer pain: the search for genetic factors correlated with interindividual variability in opioid requirement

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