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首页> 外文期刊>Plant Biotechnology Journal >Engineering of a modular and synthetic phosphoketolase pathway for photosynthetic production of acetone from CO2 in Synechococcus elongatus PCC 7942 under light and aerobic condition
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Engineering of a modular and synthetic phosphoketolase pathway for photosynthetic production of acetone from CO2 in Synechococcus elongatus PCC 7942 under light and aerobic condition

机译：浅析光电病变综合肠膜炎PCC 7942丙酮光合生产模块化和合成磷酸酶路径途径

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摘要

Capture and conversion of CO2 to valuable chemicals is intended to answer global challenges on environmental issues, climate change and energy security. Engineered cyanobacteria have been enabled to produce industry-relevant chemicals from CO2. However, the final products from cyanobacteria have often been mixed with fermented metabolites during dark fermentation. In this study, our engineering of Synechococcus elongatus PCC 7942 enabled continuous conversion of CO2 to volatile acetone as sole product. This process occurred during lighted, aerobic culture via both ATP-driven malonyl-CoA synthesis pathway and heterologous phosphoketolase (PHK)-phosphotransacetylase (Pta) pathway. Because of strong correlations between the metabolic pathways of acetate and acetone, supplying the acetyl-CoA directly from CO2 in the engineered strain, led to sole production of acetone (22.48mg/L +/- 1.00) without changing nutritional constraints, and without an anaerobic shift. Our engineered S.elongatus strains, designed for acetone production, could be modified to create biosolar cell factories for sustainable photosynthetic production of acetyl-CoA-derived biochemicals.
机译：CO2捕获和转化为宝贵的化学品旨在回答环境问题，气候变化和能源安全的全球挑战。设计的蓝细菌已成为来自二氧化碳的行业相关的化学物质。然而，来自Cyanobacteria的最终产品通常在黑发酵过程中与发酵代谢物混合。在这项研究中，我们的SyneChocccus Elongatus PCC 7942的工程使CO 2的连续转化为易丙酮作为鞋底产品。通过ATP驱动的丙二酰基-CoA合成途径和异源磷酸溶酶（PHK）途径（PTA）途径在点燃的丙酰基-CoA合成途径和异源磷酸溶酶（PTA）途径期间发生该方法。由于乙酸酯和丙酮的代谢途径之间的强关系，直接从工程菌株中的CO 2供应乙酰辅酶，导致丙酮（22.48mg / L +/- 1.00）的唯一生产而不改变营养限制，而没有厌氧转移。我们的工程化S.elongatus菌株专为丙酮生产而设计，可以进行修饰，以创建用于可持续光合作用的乙酰辅酶衍生的生物化学生物化学生物化学生物溶细胞工厂。

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