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Significant Influence of EC_(50) Estimation by Model Choice and EC_(50) Type

机译:EC_(50)估计模型选择和EC_(50)类型的显着影响

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摘要

The effective control to 50% growth inhibition (EC_(50)) is a standard statistic for evaluating dose-response relationships. Many statistical software packages are available to estimate dose-response relationships but, recently, an open source package("drc") in R has been utilized. This package is highly adaptable, having many models to describe dose-response relationships and flexibility to describe both hormetic relationships and absolute and relative EC_(50). These models and definitions are generally left out of phytopathology literature. Here, we demonstrate that model choice and type of EC5() (relative versus absolute) can matter for EC_(50) estimation using data fromPythium oopapillum and Fusarium virguliforme. For some P. oopapillum isolates, the difference between absolute and relative EC_(50) was significant. Hormetic effects changed F. virguliforme EC_(50) distributions, leading to higher estimates than when using four- or three-parameter log-logistic models. Future studies should pay careful attention to model selection and interpretation in EC_(50) estimation and clearly indicate which model and EC_(50) measure (relative versus absolute) was used. We provideguidelines for model choice and interpretation for those wishing to set up experiments for accurate EC_(50) estimation.
机译:有效控制至50%的生长抑制(EC_(50))是评估剂量 - 反应关系的标准统计。许多统计软件包可用于估计剂量 - 响应关系,但最近,已经利用了R中的开源包(“DRC”)。该包装具有很强的适应性,具有许多模型来描述剂量 - 响应关系和灵活性来描述旋转关系和绝对和相对EC_(50)。这些模型和定义通常是植物病理学文献。在这里,我们证明了EC5()(相对与绝对)的模型选择和类型,可以使用来自食品葡萄球菌和镰刀菌病毒的数据的EC_(50)估计。对于某些P. Oopapillum分离物,绝对和相对EC_(50)之间的差异很大。刺激效果改变了Virguliforme EC_(50)分布,导致比使用四或三参数日志逻辑模型时的估计更高。未来的研究应仔细注意EC_(50)估计中的模型选择和解释,并清楚地表明使用哪种模型和EC_(50)测量(相对与绝对)。我们为那些希望为精确EC_(50)估计进行建立实验的人提供模型选择和解释的娇媚。

著录项

  • 来源
    《Plant Disease》 |2018年第4期|共7页
  • 作者单位

    Department of Plant Soil and Microbial Sciences Michigan State University East Lansing 48824;

    Department of Plant Soil and Microbial Sciences Michigan State University East Lansing 48824;

    Department of Plant Soil and Microbial Sciences Michigan State University East Lansing 48824;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 植物保护;
  • 关键词

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