...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Polymer bulletin >Nanocomposite hydrogel of poly(vinyl alcohol) and biocatalytically synthesized polypyrrole as potential system for controlled release of metoprolol
【24h】

Nanocomposite hydrogel of poly(vinyl alcohol) and biocatalytically synthesized polypyrrole as potential system for controlled release of metoprolol

机译：聚（乙烯醇）的纳米复合水凝胶和生物催化合成的聚吡咯作为梅托洛尔控制释放的潜在体系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The inclusion of nanostructures into cross-linked polymer networks allows obtaining nanocomposite hydrogels with suitable multifuncionalities for drug delivery applications. In this work, polypyrrole (PPy) nanoparticles, synthesized by a biocatalytic route, were encapsulated into a hydrogel matrix of poly(vinyl alcohol) (PVA) during its reticulation with glutaraldehyde. The novel composite hydrogels were characterized by infrared spectroscopy, thermogravimetric analysis, swelling kinetic measurements, scanning electron microscopy and cyclic voltammetry. The loading capabilities of PVA/PPy hydrogels were tested for metoprolol, a beta blocker used to treat angina, hypertension and to prevent heart attack. In vitro drug release profiles were obtained without and under electrical stimulations. The kinetics of drug release exhibited a power-law time dependence, typical of hydrogel-based systems. The application of electrical potentials changed the release rate of the drug, increasing or decreasing the delivery rate depending on bias voltage. Composite system of PVA and PPy combines the electrochemical redox properties of the conductive polymer with the swelling capacity and molecular diffusivity associated with PVA network; therefore, it can be considered a potential stimuli-responsive platform for biomedical applications.
机译：将纳米结构包含到交联的聚合物网络中，允许用适合的药物递送应用获得纳米复合物水凝胶。在该作品中，通过生物催化途径合成的聚吡咯（PPY）纳米颗粒在用戊二醛网状物中包封成多凝胶凝胶基质（乙烯醇）（PVA）。通过红外光谱，热重分析，膨胀动力学测量，扫描电子显微镜和循环伏安法以新颖的复合水凝胶为特征。测试PVA / PPY水凝胶的负载能力对于甲金属托洛尔，一种用于治疗心绞痛，高血压和预防心脏病发作的β受体阻滞剂。在没有和电刺激下获得体外药物释放曲线。药物释放的动力学表现出一种基于水凝胶的系统的幂律时间依赖性。电势的应用改变了药物的释放速率，根据偏置电压增加或减少输送速率。 PVA和PPY的复合系统将导电聚合物的电化学氧化还原性与与PVA网络相关的溶胀容量和分子扩散性相结合;因此，它可以被认为是生物医学应用的潜在刺激响应平台。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号