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Synthesis and fabrication of highly functionalized Jeffamine antimicrobial polymeric coating

机译:高官能化JOFFAMINE抗微生物聚合物涂层的合成与制造

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> A simple, robust, and eco‐friendly technique for the fabrication of functionalized Jeffamine polymer in an aqueous medium is developed. The polymer is prepared by post polymerization modification of Jeffamine ED‐2003 of molecular weight 2000. The structure of the modified polymer was studied in detail using FTIR and NMR ( 1 H and 13 C NMR) spectroscopic methods. The thermal properties and degradation of the polymer were examined by DSC and TGA techniques. The polymer exhibited glass transition temperature ( T g ) at 115°C. The functionalized polymeric compound showed good antimicrobial activity against gram‐negative bacterium Escherichia coli , a tubercular variant Mycobacterium smegmatis , and gram‐positive bacterium Staphylococcus aureus with a zone of inhibition of 6 to 12, 9, and 5 to 9?mm diameter, respectively. The compound also showed good activity against the fungus, Candida albicans , with a zone of inhibition of 6 to 11?mm diameter. The morphology of the polymer films and interaction of the microbes with functionalized Jeffamine polymer were investigated by using scanning electron microscopy (SEM).
机译: > 开发了一种简单,坚固,且生态友好友好的技术,用于在水性介质中制造官能化jeffamine聚合物。通过分子量2000的jeffamine ED-2003的聚合改性来制备聚合物。使用FTIR和NMR详细研究改性聚合物的结构( 1 手 13 C NMR)光谱方法。通过DSC和TGA技术检测聚合物的热性能和降解。聚合物表现出玻璃化转变温度( t g )115°C。官能化的聚合物化合物显示出对革兰氏阴性细菌的良好抗微生物活性 大肠杆菌 ,结核变异 分枝杆菌smogmatis 和革兰氏阳性细菌 金黄色葡萄球菌 抑制区域为6至12,9和5至9Ωmm直径。该化合物还表现出对真菌的良好活性, 念珠菌albicans ,抑制区域为6至11Ωmm。通过使用扫描电子显微镜(SEM)研究了聚合物膜的形态和微生物与官能化jeffamine聚合物的相互作用。

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