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首页> 外文期刊>Polymers for advanced technologies >Coatings based on mucin-tannic acid assembled multilayers. Influence of pH
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Coatings based on mucin-tannic acid assembled multilayers. Influence of pH

机译：基于粘蛋白 - 单宁酸组装多层的涂层。 pH.的影响

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摘要

Although widely used as implantable materials due to their mechanical properties, metal devices show several disadvantages, such as the lack of cellular binding sites, antibacterial properties, or lubricant properties. To this end, the development of engineered surfaces through protein coatings has been largely investigated. Due to their natural origin and complex structure which allows the formation of hydrogels, mucins have been proposed and investigated as effective coatings for metallic implants. The present study evaluates the ability of porcine gastric mucin (PGM) to form stable coatings on a model metal surface, using three buffers with different pH values, ranging from acid to alkaline, as dispersion media. Considering its large number of hydroxyl groups and its ability to form hydrogen bonds with the protein, tannic acid (TA) was used as cross-linker. In addition to coatings' thickness and elasticity assessed through Quartz Crystal Microbalance with Dissipation monitoring (QCM-D), the study also evaluates the interactions between PGM and TA at various pH values of the dispersion media through DLS. The corroborated results show that the neutral pH allows the best interactions between PGM and TA leading to the formation of a stable, less elastic coating when compared with that obtained using as dispersion media the other two investigated buffers. Moreover, the hydrophilicity and mechanical properties of the dried coatings were assessed through contact angle measurements and nanoindentation, respectively.
机译：虽然由于其机械性能而广泛用作可植入材料，但金属装置显示出几种缺点，例如缺乏细胞结合位点，抗菌性能或润滑剂性质。为此，通过蛋白质涂料的研制表面的开发已经很大程度上已经研究。由于它们的天然来源和复杂结构，允许形成水凝胶，已经提出并研究了粘蛋白作为金属植入物的有效涂层。本研究评估猪胃粘蛋白（PGM）在模型金属表面上形成稳定涂层的能力，使用具有不同pH值的三种缓冲液，从酸到碱性，作为分散介质。考虑到其大量羟基及其与蛋白质形成氢键的能力，用单烷酸（Ta）用作交联剂。除了通过用耗散监测（QCM-D）的石英晶微观评估的涂层的厚度和弹性，研究还通过DLS评估PGM和TA之间的双pH值之间的相互作用。腐败的结果表明，中性pH允许PGM和TA之间的最佳相互作用导致形成稳定，较少的弹性涂层，与其他两种研究的缓冲液相比，与分散培养物相比。此外，通过接触角测量和纳米凸缘评估干燥涂层的亲水性和机械性能。

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