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首页> 外文期刊>Polymers for advanced technologies >Injectable poloxamer/graphene oxide hydrogels with well‐controlled mechanical and rheological properties
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Injectable poloxamer/graphene oxide hydrogels with well‐controlled mechanical and rheological properties

机译：具有良好控制的机械和流变性能的可注射泊洛沙姆/石墨烯氧化物水凝胶

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>Although significant progress has been made in the design and application of injectable hydrogels for biomedical applications, concurrent control of rheological and mechanical properties of injectable hydrogels has remained as an open challenge to the researchers. In this work, we introduce and put into practice a photo‐curable poloxamer (also known as Pluronic)/graphene oxide (Plu/GO) injectable hydrogel with well‐controlled rheological and mechanical properties. Acrylate group was anchored to hydrogel structure to endow photo‐crosslinking ability through decelerating degradation rate of poloxamer hydrogels after injection. It was found that the modified Plu remains stable in biological media for a long‐term period without significant weight loss. Rheological properties of hydrogels were also carried out as essential prerequisite for an ideal injectability via frequency sweep, flow curve, recovery, and yield stress before and after modification, signifying shear‐thinning behavior of Plu/GO hydrogels with high recoverability. The viscosity of shear‐thinning‐like hydrogels dropped at higher shear stress, which facilitated injection process. Moreover, mechanical behavior of Plu was optimized by manipulating the content of Plu, degree of modification with reactive precursor, curing, and particularly incorporation of GO without deteriorating effects on rheological behavior of Plu.
机译： 虽然在生物医学应用的注射水凝胶的设计和应用方面取得了显着进展，但可注射水凝胶的流变和力学性能的并行控制仍然是对研究人员的开放挑战。在这项工作中，我们介绍并实施了具有良好控制的流变和机械性能的可光固化泊洛克马酯（也称为Pluronic）/石墨烯（PLU / GO）注射水凝胶。丙烯酸酯基团锚定通过在注射后的泊洛沙姆水凝胶的降解速率减少衍生光交联能力。发现改性的PLU在生物介质中保持稳定，长期期间没有显着减肥。水凝胶的流变性质也是通过频率扫描，流动曲线，恢复和修饰前后和之后的理想可注射性的基本前述性的必要性前提条件进行，其在修饰之前和之后，具有高可回收性的PLU / GO水凝胶的剪切变薄行为。剪切薄膜状水凝胶的粘度下降在较高的剪切应力下，促进注射过程。此外，通过操纵PLU的含量，具有反应性前体，固化性的改性程度，固化，特别掺入GO而不会降低对PLU的流变行为的影响，优化了PLU的力学行为。

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