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首页> 外文期刊>Polymers for advanced technologies >Molecularly imprinted polymer nanocarriers for recognition and sustained release of diclofenac
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Molecularly imprinted polymer nanocarriers for recognition and sustained release of diclofenac

机译：分子印迹聚合物纳米载体用于识别和持续释放双氯芬酸

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> In this study, a series of imprinted poly(methacrylic acid‐ co ‐ethylene glycol dimethacrylate) nanocarriers for diclofenac and corresponding nonimprinted polymer nanocarriers have been synthesized in 4 different types of solvents by precipitation polymerization. The products were characterized by Fourier transform infrared, scanning electron microscopy, dynamic light scattering, and Brunauer‐Emmett‐Teller measurement. Results showed that uniformly sized molecularly imprinted polymer (MIP) nanospheres with relatively good porosity could only be obtained in acetonitrile. The effects of solvents on the recognition and release properties of polymer particles were also carefully investigated. The binding experiments indicated that MIPs prepared in acetonitrile displayed much higher binding capacity than other MIPs with a maximum binding capacity of 65.18?mg?g ?1 . The Scatchard analysis showed that synthetic MIPs have special recognition sites for diclofenac, while nonimprinted polymers have not. The Sips model could provide a best fit to the equilibrium data of nanocarriers over whole concentrations. The experimental data of an adsorption kinetic study were well fitted to the pseudo–second‐order kinetic model, indicating the chemisorption mechanism between diclofenac and MIPs in the process of adsorption. The drug release of diclofenac from MIPs could well be described by the Ritger‐Peppas model, suggesting a non‐Fickian diffusion mechanism. In addition, we successfully used MIPs to extract diclofenac at low levels from fetal bovine serum.
机译： >在本研究中，一系列印迹聚（甲基丙烯酸 - 二氯芬酸的CO - 乙二醇二甲基丙烯酸酯纳米载体通过沉淀聚合用4种不同类型的溶剂合成了二氯芬克酸和相应的非视为聚合物纳米载体。该产品的特点是傅里叶变换红外，扫描电子显微镜，动态光散射和Brunauer-Emmett-extorer测量。结果表明，只能在乙腈中获得具有相对良好的孔隙率的均匀大小的分子印迹聚合物（MIP）纳米球。还小心地研究了溶剂对聚合物颗粒的识别和释放性质的影响。结合实验表明，在乙腈中制备的MIPS比其他MIP显示的最大结合容量为65.18Ω·mg≤1/ sup>。 Scatchard分析表明，合成MIPS具有DICLOFENAC的特殊识别位点，而非视网膜聚合物没有。 SIPS模型可以通过整个浓度提供最适合纳米载波的均衡数据。吸附动力学研究的实验数据适合于伪二阶动力学模型，表明在吸附过程中双氯芬酸和MIPS之间的化学吸附机制。 RITGER-PEPPAS模型可以描述双氯芬酸的药物释放，旨在描述非FICISIAN扩散机制。此外，我们成功地使用MIPS从胎牛血清的低水平提取双氯芬酸。

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