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首页> 外文期刊>Polymers for advanced technologies >Polycaprolactone/chitosan blend nanofibers loaded by 5‐fluorouracil: An approach to anticancer drug delivery system
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Polycaprolactone/chitosan blend nanofibers loaded by 5‐fluorouracil: An approach to anticancer drug delivery system

机译：由5-氟尿嘧啶装载的聚己内酯/壳聚糖混合物纳米纤维：抗癌药物递送系统的方法

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>Cancer is one of the most common causes of death worldwide. Inability in controlling anticancer drug delivery to tumor, systemic side effect on healthy tissue, instability of anticancer drugs, low concentration of drug around the tumor, and low efficiency of drug effect on the solid tumor may cause high mortality rate in cancer patients. Drug delivery systems based on nanofibers could perform an approach to treat cancer with the least side effects. The aim of this study is to improve a nanofiber drug delivery system based on polycaprolactone/chitosan blended electrospun nanofibers containing 5‐fluorouracil. Nanofiber characteristics and drug release behavior of various nanofibers were investigated. The polymeric proportion had significant effect on release behavior, mechanical properties, and nanofiber morphology. Loading efficiency of these nanofibrous drug delivery systems was good, and its rate increased by increasing chitosan proportion. Also, increasing the chitosan in nanofibers led to increasing drug release period. The release mechanism of all nanofibers was Fickian diffusion according to Korsmeyer‐Peppas model. This nanofibrous drug delivery system had a great potential to perform an anticancer drug delivery system for colorectal cancer. Further studies need to be conducted to improve the release period of 5‐fluorouracil from these nanofibers.
机译： >癌症是全世界最常见的死亡原因之一。无法控制抗癌药物递送给肿瘤，全身副作用对健康组织，抗癌药物的不稳定性，肿瘤周围的药物低，药物效果低的药物效果可能导致癌症患者的高死亡率。基于纳米纤维的药物递送系统可以进行一种治疗癌症的方法，以最少的副作用治疗癌症。该研究的目的是改善基于含有5-氟尿嘧啶的聚己内酯/壳聚糖混合电纺纳米纤维的纳米纤维药物输送系统。研究了各种纳米纤维的纳米纤维特性和药物释放行为。聚合物比例对释放行为，机械性能和纳米纤维形态具有显着影响。这些纳米纤维药物递送系统的加载效率良好，通过增加壳聚糖比例来增加其速率。此外，增加纳米纤维的壳聚糖导致药物释放期的增加。所有纳米纤维的释放机制是根据Korsmeyer-Peppas模型的Fickian扩散。这种纳米纤维的药物递送系统具有对结直肠癌进行抗癌药物递送系统的潜力很大。需要进行进一步的研究以改善来自这些纳米纤维的5-氟尿嘧啶的释放期。

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