...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Polymers for advanced technologies >Load-bearing biodegradable polycaprolactone-poly (lactic-co-glycolic acid)- beta tri-calcium phosphate scaffolds for bone tissue regeneration
【24h】

Load-bearing biodegradable polycaprolactone-poly (lactic-co-glycolic acid)- beta tri-calcium phosphate scaffolds for bone tissue regeneration

机译：承载可生物降解的聚己内酯 - 聚（乳酸二乙醇酸） - β三钙磷酸钙支架，用于骨组织再生

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A biodegradable scaffold with tissue ingrowth and load-bearing capabilities is required to accelerate the healing of bone defects. However, it is difficult to maintain the mechanical properties as well as biodegradability and porosity (necessary for bone ingrowth) at the same time. Therefore, in the present study, polycaprolactone (PCL) and poly (lactic-co-glycolic acid) (PLGA5050) were mixed in varying ratio and incorporated with 20 wt.% beta tri-calcium phosphate (beta TCP). The mixture was shaped under pressure into originally nonporous cylindrical constructs. It is envisioned that the fabricated constructs will develop porosity with the time-dependent biodegradation of the polymer blend. The mechanical properties will be sustained since the decrease in mechanical properties associated with the dissolution of the PLGA, and the formation of the porous structure will be compensated with the new bone formation and ingrowth. To prove the hypothesis, we have systematically studied the effects of samples composition on the time-dependent dissolution behavior, pore formation, and mechanical properties of the engineered samples, in vitro. The highest initial (of as-prepared samples) values of the yield strength (0.021 +/- 0.002 GPa) and the Young's modulus (0.829 +/- 0.096 GPa) were exhibited by the samples containing 75 wt.% of PLGA. Increase of the PLGA concentration from 25 to 75 wt.% increased the rate of biodegradation by a factor of 3 upon 2 weeks in phosphate buffered saline (1 x PBS). The overall porosity and the pore sizes increased with the dissolution time indicating that the formation of in situ pores can indeed enable the migration of cells followed by vascularization and bone growth.
机译：需要一种可生物降解的支架，具有组织的成向和承载能力来加速骨缺损的愈合。然而，难以同时保持机械性能以及生物降解性和孔隙率（必需的骨骼）。因此，在本研究中，聚己内酯（PCL）和聚（乳酸 - 共乙醇酸）（PLGA5050）以不同的比例混合并掺入20重量％的β三钙磷酸盐（βTCP）。将混合物成形为压力为最初的无孔圆柱形构建体。设想，制造的构建体将开发具有聚合物共混物的时间依赖性生物降解的孔隙率。由于与PLGA溶解相关的机械性能的降低，并且形成多孔结构的机械性能降低，因此将持续持续性质，并且将用新的骨形成和成根来补偿。为了证明假设，我们已经系统地研究了样品组合物在体外改进样品的时间依赖性溶解行为，孔隙形成和机械性能的影响。通过含有75重量％的样品，含有75重量％的样品，含有75重量％的样品，含有屈服强度（0.021 +/- 0.002GPa）和杨氏模量（0.829 +/- 0.096GPa）的最高初始（0.021 +/- 0.002GPa）的值。将PLGA浓度的增加从25-75重量％增加。％在磷酸盐缓冲盐水（1×PBS）中在2周内将生物降解率增加3。通过溶解时间增加了整体孔隙率和孔径，表明原位孔的形成确实能够使细胞迁移随后血管化和骨生长。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号