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首页> 外文期刊>Polymers for advanced technologies >Recent progress in the development of immobilized penicillin G acylase for chemical and industrial applications: A mini‐review
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Recent progress in the development of immobilized penicillin G acylase for chemical and industrial applications: A mini‐review

机译：固定化青霉素G acylase进行化学和工业应用的近期进展：迷你审查

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摘要

>Immobilized penicillin G acylase (PGA) as an important industrial catalyst can catalyze penicillin G potassium (PG) to 6‐aminopenicillanic acid (6‐APA). 6‐APA is an important intermediate for semisynthetic penicillin drugs, which occupies a huge market space in the anti‐inflammatory field; as a result, immobilized PGA occupies a huge market space in the pharmaceutical field. However, at present, there are different degrees of defects in the preparation and production process of immobilized PGAs on the market because of the huge demand; therefore, the performance of immobilized PGA and its productivity will bring huge economic benefits to enterprises. Therefore, research on immobilized PGA has always been a focus. This review first introduces the source, classification, structure, and catalytic mechanism of PGA and then studies the development of immobilization methods, immobilized carriers, reaction media, enzyme activity regeneration, and reactors of immobilized PGA in recent years.
机译： >固定化的青霉素G酰化酶（PGA）作为重要的工业催化剂可以催化青霉素G钾（PG）至6-氨基丙酸（6-APA）。图6-APA是半合成青霉素药物的重要中间，占据了抗炎领域的巨大的市场空间;因此，固定的PGA占据了药物领域的巨大的市场空间。然而，目前，由于需求巨大，在市场上固定的PGA的制备和生产过程中存在不同程度的缺陷;因此，固定的PGA的性能及其生产力将为企业带来巨大的经济效益。因此，对固定的PGA的研究一直是焦点。本综述首先介绍了PGA的源，分类，结构和催化机制，然后研究了近年来固定的PGA的固定方法，固定化载体，反应介质，酶活性再生和固定PGA的反应器。

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  • 来源
    《Polymers for advanced technologies》 |2020年第3期|共21页
  • 作者

    Li Ke; Mohammed Monier Alhadi Abdelrahman; Zhou Yongshan; Tu Hongyi; Zhang Jiachen; Liu Chunli; Chen Zhenbin; Burns Robert; Hu Dongdong; Ruso Juan M.; Tang Zhenghua; Liu Zhen;

  • 作者单位

    State Key Laboratory of Gansu Advanced Non‐ferrous Metal MaterialsLanzhou University of TechnologyLanzhou China;

    State Key Laboratory of Gansu Advanced Non‐ferrous Metal MaterialsLanzhou University of TechnologyLanzhou China;

    State Key Laboratory of Gansu Advanced Non‐ferrous Metal MaterialsLanzhou University of TechnologyLanzhou China;

    State Key Laboratory of Gansu Advanced Non‐ferrous Metal MaterialsLanzhou University of TechnologyLanzhou China;

    State Key Laboratory of Gansu Advanced Non‐ferrous Metal MaterialsLanzhou University of TechnologyLanzhou China;

    State Key Laboratory of Gansu Advanced Non‐ferrous Metal MaterialsLanzhou University of TechnologyLanzhou China;

    State Key Laboratory of Gansu Advanced Non‐ferrous Metal MaterialsLanzhou University of TechnologyLanzhou China;

    Department of Physics and EngineeringFrostburg State UniversityFrostburg Maryland;

    State Key Laboratory of Chemical EngineeringEast China University of Science and TechnologyShanghai China;

    Soft Matter and Molecular Biophysics Group Department of Applied PhysicsUniversity of Santiago de CompostelaSantiago de Compostela Spain;

    Guangzhou Key Laboratory for Surface Chemistry of Energy MaterialsNew Energy Research InstituteSchool of Environment and Energy South China University of Technology Guangzhou Higher Education Mega Centre Guangzhou China;

    Department of Physics and EngineeringFrostburg State UniversityFrostburg Maryland;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 高分子化合物工业（高聚物工业）;
  • 关键词

    carrier; immobilization; penicillin G acylase; reaction; reactor;

    机译：载体;固定化;青霉素G酰化酶;反应;反应器;

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