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首页> 外文期刊>Polymers for advanced technologies >Hyaluronic acid-poly(vinyl alcohol) composite cryo-gel for biofunctional material application
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Hyaluronic acid-poly(vinyl alcohol) composite cryo-gel for biofunctional material application

机译：透明质酸 - 聚（乙烯醇）复合胶乳用于生物功能材料应用

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Recently, applications of hyaluronic acid (HA) as a biomaterial were investigated. However, the weak structure of HA gel and the effects of using cross-linker raised concerns during in vivo resolution. In this study, we investigated the method to solve these two problems using physical cross-linking and compositing with poly(vinyl alcohol) (PVA). Various weight ratios of HA and PVA solutions were mixed, adjustment of pH to 1.8 using HCl then used to fabricate HA-PVA cryo-gel by freezing-thawing. Young's modulus of the prepared gel rose with the increase of both HA and PVA concentrations or either one of them. We estimated that HA and PVA have exhibited these mechanical properties due to forming a double network. HA-PVA gel showed kinetic friction force of approximately 10 times of PVA gel, while water contact angle and protein adsorption of HA-PVA gels were remarkably decreased. The properties of the prepared gel suggest that it can be used for postoperative adhesion prevention applications.
机译：最近，研究了透明质酸（HA）作为生物材料的应用。然而，HA凝胶的弱结构以及使用交联剂在体内分辨率期间提出了担忧的效果。在这项研究中，我们研究了使用物理交联和与聚（乙烯醇）（PVA）合成来解决这两个问题的方法。将HA和PVA溶液的各种重量比混合，使用HCl调节pH至1.8，然后通过冷冻解冻制造HA-PVA冷冻凝胶。杨氏模量随着HA和PVA浓度的增加或其中任何一个。由于形成双网络，我们估计HA和PVA由于形成双网络而表现出这些机械性能。 HA-PVA凝胶显示出大约10次PVA凝胶的动力学摩擦力，而HA-PVA凝胶的水接触角和蛋白质吸附显着降低。制备的凝胶的性质表明它可用于术后粘附预防应用。

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