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首页> 外文期刊>Poultry Science >Breed-related differences in age-dependent down-regulation of the beta(1)-adrenoceptor and adenylate cyclase activity in atrial and ventricular myocardium of Crollwitzer ('wild-type') turkeys
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Breed-related differences in age-dependent down-regulation of the beta(1)-adrenoceptor and adenylate cyclase activity in atrial and ventricular myocardium of Crollwitzer ('wild-type') turkeys

机译：群体依赖性下调β（1） - 克罗特韦策（“野生型”）火鸡（“野生型”）的年龄依赖性下调和腺苷酸环化酶活性的繁殖差异

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摘要

In conventional meat-type (British United Turkey (B.U.T.) Big 6) turkey hearts, it has been shown that all cardiac chambers exhibit down-regulation of the beta(1)-adrenoceptors (beta(1)-AR) and concomitantly cAMP accumulation with increasing age regardless of sex. In this study we proved the hypothesis that breed differences exist in age-dependent alterations in the beta(1)-AR system. Right (RA) and left (LA) atrial as well as right (RV) and left (LV) ventricular tissues were collected from male and female Crollwitzer "wild-type" turkey poults of increasing age (6 wk, 12 wk, 16 wk, 21 wk). The beta(1)-AR density and function were quantified by (-)-[I-125]-iodocyanopindolol (ICYP) radioligand binding analysis in cell membranes from 4 cardiac chambers. Basal and stimulated cAMP production was determined as indicator of the receptor function. Wild-type turkeys showed significantly higher heart to body weight ratio than the meat-type B.U.T. Big 6 turkeys. In both sexes of Crollwitzer turkey hearts, the beta(1)-AR density decreased with age but significance was reached in male cardiac chambers. The receptor affinity (K-D) and subtype distribution were not altered. Sex had no effect on age-related decrease in receptor density but had an effect on adenylate cyclase (AC) activity and subsequently cAMP production. In male Crollwitzer turkey hearts of all ages, cAMP remained at same level, whereas this was even increased in female cardiac chambers. Thus, breed affected age-related receptor-, G-protein and AC-stimulated cAMP formation in normal ventricles and atria, with females exhibiting pronounced increase with age. This suggests that the receptor signaling in wild-type turkey hearts is not as blunted as in hearts of meat-type turkey poults in which stressful farming conditions and fast growing lead to receptor down-regulation.
机译：在传统的肉类（英国联合土耳其（但）大6）土耳其心中，已经表明所有心脏腔室都表现出β（1） - β（β（1）-AR）并伴随营地积累随着年龄的增加，无论性行为。在这项研究中，我们证明了诸如β（1）-AR系统的年龄依赖性改变存在繁殖差异的假设。从男性和女性峡谷“野生型”土耳其池中收集右（Ra）和左（La）和左（RV）和左（LV）心室组织（6 WK，12周，16周，21周）。 β（1）-AR密度和功能由来自4个心室的细胞膜中的（ - ） - [I-125] - 碘氰基醇（ICYP）放射性配体结合分析量化。基础和刺激的阵营生产被确定为受体功能的指标。野生型火鸡与肉类型B.U.T的体重比表现出显着较高的心脏。大6个火鸡。在克罗尔韦策的两性中，β（1）-AR密度随着年龄的增长而降低，但在雄性心脏室中达到了意义。受体亲和力（K-D）和亚型分布未被改变。性对受体密度的年龄有关的降低没有影响，但对腺苷酸环化酶（AC）活性和随后的营养产生影响。在所有年龄段的男性克罗夫策策枪的火鸡心中，营地保持在同一水平，而这件甚至在女性心房甚至增加。因此，繁殖受影响的年龄相关的受体 - ，G-蛋白和Ac刺激的营养营形成正常的心室和Atria，雌性随着年龄的增长而表现出明显的增加。这表明野生型火鸡心中的受体信号传导不如在肉类型火鸡泥的心中那么钝，其中压力养殖条件和快速增长导致受体下调。

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