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Antiviral effect of baicalin phospholipid complex against duck hepatitis A virus type 1

机译：黄芩苷磷脂复合物对鸭甲型肝炎的抗病毒作用1型病毒1

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摘要

Duck hepatitis A virus type 1 (DHAV-1) is one of the main pathogens of ducklings and causes a high mortality rate. Baicalin (BA) has potent antiviral effect, but the solubility is very poor. In order to increase the absorption, solubility, and pharmacological activity, the phospholipid complex was used to modify BA in present study. Therefore, BA phospholipid complex (BAPC) was prepared. The anti-DHAV-1 abilities of BA and BAPC in vitro was evaluated by cell counting kit-8 and reverse transcription quantitative PCR. The curative effects of BA and BAPC on ducklings which were infected by DHAV-1 in addition to the ALT and AST levels were also detected. The results indicated the anti-DHAV-1 ability of BAPC was stronger than that of BA both in vitro and in vivo. To explore the anti-DHAV-1 mechanism, the influence of BAPC on DHAV-1 adsorption, replication, and release was studied. Furthermore, the anti-oxidative and immuno-enhancing abilities of BAPC in the treatment of infected ducklings were also determined. The results showed BAPC inhibited DHAV-1 adsorption, replication and release. Furthermore, it played anti-oxidative and immno-enhancing roles in the treatment, and the immno-enhancing role was crucial to the treatment.
机译：鸭丙型肝炎病毒类型1（DHAV-1）是鸭鱼的主要病原体之一，并导致高死亡率。黄芩苷（BA）具有有效的抗病毒效果，但溶解度非常差。为了增加吸收，溶解度和药理活性，磷脂复合物用于在现有研究中修饰Ba。因此，制备了BA磷脂络合物（BAPC）。通过细胞计数试剂盒-8和逆转录定量PCR评估BA和BAPC的抗DHAV-1能力。还检测了除ALT和AST水平外，BA和BAPC对DHAV-1感染的鸭子的疗效。结果表明BAPC的抗DHAV-1能力比体外和体内均为BA的抗DHAV-1能力。为了探索抗DHAV-1机制，研究了BAPC对DHAV-1吸附，复制和释放的影响。此外，还确定了BAPC治疗感染鸭肉的抗氧化和免疫增强能力。结果显示BAPC抑制DHAV-1吸附，复制和释放。此外，它在治疗中发挥了抗氧化和免疫增强作用，并且免疫增强作用对治疗至关重要。

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  • 来源
    《Poultry Science》 |2018年第8期|共11页
  • 作者

    Chen Y.; Yang Y.; Wang F.; Yang X.; Yao F.; Ming K.; Yuan W.; Zeng L.; Liu J.;

  • 作者单位

    Nanjing Agr Univ Inst Tradit Chinese Vet Med Coll Vet Med Nanjing 210095 Jiangsu Peoples R China;

    Hainan Univ Coll Anim Sci &

    Technol Coll Trop Agr &

    Forestry Anim Genet Engn Key Lab Hainan Key Lab Trop Anim Reprod &

    Breeding &

    Epid Haikou 570228 Hainan Peoples R China;

    Hainan Univ Coll Anim Sci &

    Technol Coll Trop Agr &

    Forestry Anim Genet Engn Key Lab Hainan Key Lab Trop Anim Reprod &

    Breeding &

    Epid Haikou 570228 Hainan Peoples R China;

    Hainan Univ Coll Anim Sci &

    Technol Coll Trop Agr &

    Forestry Anim Genet Engn Key Lab Hainan Key Lab Trop Anim Reprod &

    Breeding &

    Epid Haikou 570228 Hainan Peoples R China;

    Nanjing Agr Univ Inst Tradit Chinese Vet Med Coll Vet Med Nanjing 210095 Jiangsu Peoples R China;

    Nanjing Agr Univ Inst Tradit Chinese Vet Med Coll Vet Med Nanjing 210095 Jiangsu Peoples R China;

    Nanjing Agr Univ Inst Tradit Chinese Vet Med Coll Vet Med Nanjing 210095 Jiangsu Peoples R China;

    Anim Husb &

    Vet Bur Yuhang Dist Hangzhou Hangzhou 311100 Zhejiang Peoples R China;

    Nanjing Agr Univ Inst Tradit Chinese Vet Med Coll Vet Med Nanjing 210095 Jiangsu Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 畜牧、动物医学、狩猎、蚕、蜂;
  • 关键词

    baicalin; phospholipid complex; antiviral mechanism; Duck hepatitis A virus type 1;

    机译：黄芩苷;磷脂复合物;抗病毒机制;鸭甲型肝炎病毒1型;

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