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首页> 外文期刊>BJU international >Thrombotic risk factors associated with transurethral prostatectomy.
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Thrombotic risk factors associated with transurethral prostatectomy.

机译：经尿道前列腺切除术相关的血栓危险因素。

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OBJECTIVE: To ascertain the potential thrombotic risk associated with transurethral prostatectomy (TURP). PATIENTS AND METHODS: The changes in coagulation variables were assessed in a prospective study of 40 patients undergoing TURP. RESULTS: There was a significant increase in thrombin-antithrombin complexes 6 h after TURP (anova, P=0.01) combined with a significant decrease in activated partial thromboplastin time (anova, P=0.006), suggesting a postoperative hypercoagulable state. The significant increase in d-dimer 24 h after TURP (anova, P=0.015) in the absence of any significant rise in tissue plasminogen activator antigen levels perioperatively (anova, P=0.737) suggests a physiological fibrinolytic response to the developing procoagulant state. The absence of any significant increase in plasminogen activator inhibitor-1 antigen perioperatively (anova, P=0.348) suggests the observed hypercoagulability is not due to a 'fibrinolytic shutdown' reported in other forms of surgery. CONCLUSION: TURP is associated with a hypercoagulable prothrombotic state; aspirin withdrawal perioperatively may be hazardous, and low-dose heparin prophylaxis for venous thrombosis should be considered.
机译：目的：确定与经尿道前列腺切除术（TURP）相关的潜在血栓风险。患者和方法：在一项对40名接受TURP的患者的前瞻性研究中评估了凝血变量的变化。结果：TURP后6 h凝血酶-抗凝血酶复合物显着增加（NOVAA，P = 0.01），同时激活的部分凝血活酶时间显着减少（NOVAA，P = 0.006），提示术后处于高凝状态。 TURP术后24小时d-二聚体的显着增加（无新陈代谢，P = 0.015），而围手术期组织纤溶酶原激活物抗原水平没有任何显着升高（无新陈代谢，P = 0.737）表明对发展中的促凝状态有生理上的纤溶反应。围手术期纤溶酶原激活物抑制剂1抗原没有任何显着增加（方差分析，P = 0.348）表明观察到的高凝性不是由于其他形式的手术中报告的“纤溶关闭”所致。结论：TURP与高凝性血栓前状态有关。围手术期停用阿司匹林可能是危险的，应考虑小剂量肝素预防静脉血栓形成。

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