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首页> 外文期刊>Prehospital emergency care >Evaluation of extremity tissue and bone injury after intraosseous hypertonic saline infusion in proximal tibia and proximal humerus in adult swine
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Evaluation of extremity tissue and bone injury after intraosseous hypertonic saline infusion in proximal tibia and proximal humerus in adult swine

机译：胫骨近端胫骨血液盐水输注后末端组织和骨损伤的评价

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Background. Hypertonic saline (HTS) has been reported as a treatment for sever traumatic brain injury and hemorrhagic shock and current clinical guidelines recommend it. Intraosseous (IO) infusion is often needed in the pre-hospital and combat settings to administer life-saving treatments. However, the safety of IO HTS infusion is not clear. The aim of our study was to evaluate the clinical and histological outcome of HTS IO infusion into the extremity of a large animal model.Methods. We conducted a randomized comparative study of adult pigs that were infused intraosseously with one of the following solutions: 7.5% HTS, 3% HTS or normal 0.9% isotonic saline. The animals were observed daily for infection, necrosis and gait (5 point Tarlov score) up to 5 days. Five days after infusion, necropsy and histological analysis was performed using a validated scale of tissue necrosis.Results. The mean Tarlov gait scores were similar in all arms and all animals showed a score of 4 (normal ambulation) by day 5. During the 5 day observation period, there were no signs of infection or tissue abnormalities. Histological examinations showed no indication of necrosis, or abnormal bone and muscle healing (p < 0.05).Conclusion. We observed regular tissue morphology and normal gait scores over the 5 day observation period. There was an absence of gross tissue necrosis and microscopic ischemia post IO HTS infusion in this swine model. This data confirms the clinical safety of IO HTS infusion and highlights its use as an alternative lifesaving treatment.
机译：背景。高渗盐水（HTS）已被报告为切割创伤性脑损伤和出血性休克和目前的临床指南推荐的治疗。在医院预科和战斗环境中通常需要骨内（IO）输注，以管理救生治疗方法。然而，IO HTS输注的安全性尚不清楚。我们的研究目的是评估HTS IO输注的临床和组织学结果进入大型动物模型的极端。方法。我们对成年猪进行了一项随机对比研究，其用以下溶液中的一种进行了骨内注入：7.5％HT，3％HTS或正常的0.9％等渗盐水。每天观察动物，用于感染，坏死和步态（5点Tarlov得分）长达5天。输注后五天，使用验证的组织坏死量进行尸检和组织学分析。结果。在所有武器中，平均Tarlov步态得分类似，所有动物都显示出4天（正常气动）的分数。在5天观察期间，没有感染或组织异常的迹象。组织学检查显示没有坏死或异常骨骼和肌肉愈合的指示（P <0.05）。结论。在5天观察期间，我们观察到常规组织形态和正常步态分数。这种猪模型中没有病原体坏死和微观缺血术后IO HTS输注。该数据证实了IO HTS输注的临床安全，并突出了其作为替代救生治疗的用途。

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