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Intraosseous Pressure Monitoring in Healthy Volunteers

机译：健康志愿者的骨质压力监测

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Study Objective: Invasively monitoring blood pressure through the IO device has not been thoroughly demonstrated. This study attempted to establish baseline values of IO pressure in a healthy human population. Methods: This was a prospective, healthy volunteer, observational study. Participants had two IO devices placed (humerus and tibia), and participant IO pressures, vital signs, and pain scores were monitored for up to 60minutes. Participants were contacted at 24-hours and 7days post-testing to assess for adverse events. Summary statistics were calculated for systolic, diastolic, and mean humeral and tibial IO pressure. The ratio of IO to non-invasive blood pressure was calculated, and Bland Altman plots were created. The slope (linear) of the mean humeral and the tibial IO pressures were also calculated. Results: Fifteen subjects were enrolled between April and July 2015. Fourteen of 15 humeral IOs were placed successfully (93.3%) and all 15 of the tibial IOs were placed successfully. Mean tibial systolic, diastolic, and mean IO pressure were 55.8 +/- 27.9, 49.3 +/- 27.1, and 48.4 +/- 29.4mm Hg, respectively. Humeral systolic, diastolic, and mean IO pressure were 32.9 +/- 16.0, 27.4 +/- 15.2, and 24.5 +/- 14.3mm Hg. The mean tibial IO pressure was 52.5% +/- 32.0% of external cuff pressure ratio. The mean humeral IO pressure was 26.5% +/- 15.2% of the external mean blood pressure. The Bland Altman plots showed an inconsistent relationship between the systolic and diastolic cuff pressure and the IO pressures. We observed a 1% per minute decrease in IO pressure from the initial placement until the final reading. Conclusions: Intraosseous pressure readings can be obtained in healthy human volunteers. However, absolute IOP values were not consistent between subjects. Future research may determine how IO pressure can be used to guide therapy in ill and injured patients.
机译：研究目标：通过IO设备侵入地监测血压尚未彻底展示。本研究试图在健康人口中建立IO压力的基线值。方法：这是一项潜在，健康的志愿者，观察研究。参与者有两个IO设备（Humerus和Tibia），以及参与者的IO压力，生命体征和疼痛分数可监测高达60分钟。与会者在24小时和7天的测试后与参与者接触，以评估不利事件。针对收缩，舒张性和均值肱骨和胫骨IO压力计算统计数据。计算IO与非侵入性血压的比率，并创建了Bland Altman图。还计算了平均肱骨和胫骨IO压力的斜坡（线性）。结果：2015年4月和7月之间的十五个科目在4月和7月之间招募.15个肱骨IOS成功（93.3％），所有15个胫骨IOS都成功地放置。平均胫骨收缩，舒张性，平均压力分别为55.8 +/- 27.9,49.3 +/- 27.1和48.4 +/- 29.4mm hg。肱骨收缩，舒张性，平均压力为32.9 +/- 16.0,27.4 +/- 15.2和24.5 +/- 14.3mm。平均胫骨IO压力为外部袖带压力比的52.5％+/- 32.0％。平均肱骨IO压力为26.5％+/- 15.2％的外部平均血压。 Bland Altman Plots在收缩系和舒张袖压和IO压力之间表现出不一致的关系。从初始放置到最终读数之前，我们观察到IO压力下降1％的减少。结论：可以在健康的人志愿者中获得骨内压读数。但是，受试者之间的绝对IOP值并不一致。未来的研究可以确定IO压力如何用于引导患者和受伤患者的治疗。

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