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Prehospital Application of Hemostatic Agents in Iraq and Afghanistan

机译:伊拉克与阿富汗止血剂的预挖掘应用

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Introduction: Hemorrhage is the leading cause of death on the battlefield. Development of chitosan- and kaolin-based hemostatic agents has improved hemorrhage control options. Sparse data exists on the use of these agents in the prehospital, combat setting. We describe recent use of these agents and compare patients receiving hemostatic to the baseline population. Methods: We used a series of emergency department (ED) procedure codes to identify patients within the Department of Defense Trauma Registry (DODTR) from January 2007 to August 2016. We only included patients for whom the DODTR specified the hemostatic agent utilized (chitosan or kaolin). We defined a serious injury by body region as an Abbreviated Injury Score (AIS) of 3 or greater. Results: Our predefined search codes captured 28,222 patients. Of those, 258 (0.9%) patients had documented hemostatic use: 58 chitosan, 201 kaolin, and one subject received both. Patients undergoing hemostatic agent application were more likely to be injured by gunshot wound or explosive. Patients with hemostatic application had higher median composite Injury Severity Scores (10 vs. 9, p 0.001), and higher AIS for the abdomen, extremity and superficial body regions with higher rates of blood product utilization. Proportions of patients suffering traumatic amputations and undergoing tourniquet application were higher in the hemostatic agent group than the baseline population (11.6% vs. 6.7%, p = 0.002 and 43.4% vs. 13.8%, p 0.001, respectively). Conclusions: Hemostatic agents were infrequently utilized to manage traumatic hemorrhage during the recent conflicts in Afghanistan and Iraq. Hemostatic agent use was more frequent in casualties with gunshot wounds, traumatic amputations, concomitant tourniquet application, and greater blood product administration.
机译:介绍:出血是战场上死亡的主要原因。壳聚糖和高岭土的止血剂的发展具有改善的出血控制选项。在预讨论,战斗设置中使用这些代理时存在稀疏数据。我们描述了最近使用这些药剂并比较接受止血到基线人群的患者。方法:我们使用一系列急诊部门(ED)程序代码,从2007年1月至2016年8月识别防御创伤署注册管理机构(Dodtr)内的患者。我们只包括Dodtr指定所使用的止血剂的患者(壳聚糖或高岭土)。我们将身体区域的严重伤害定义为3或更大的缩写伤害得分(AIS)。结果:我们的预定义搜索代码捕获了28,222名患者。其中,258例(0.9%)患者患有止血用途:58壳多糖,201高岭土,以及两项受试者。经过止血剂应用的患者更有可能被枪伤或爆炸性伤害。止血患者的患者具有较高的中值复合损伤严重性分数(10 vs.9,P <0.001),腹部,肢体和浅表面积的较高AIS,具有较高的血液产品利用率。的痛苦创伤性截肢和经受止血带应用患者的比例比基线人口止血剂组中较高(11.6%对6.7%,P = 0.002和43.4%对13.8%,P&LT; 0.001)。结论:在最近的阿富汗和伊拉克的冲突中,止血剂常常用于管理创伤出血。止血剂在枪伤,创伤截肢,伴随止血带应用以及更高的血液产品施用时更频繁地使用止血剂在伤亡中更频繁。

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