> In the present work, the application of functional coatings on metallic implants was proposed to delay implant failure by improv'/> PEG‐based organic–inorganic hybrid coatings prepared by the sol–gel dip‐coating process for biomedical applications
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PEG‐based organic–inorganic hybrid coatings prepared by the sol–gel dip‐coating process for biomedical applications

机译：通过溶胶 - 凝胶浸涂方法制备的PEG基有机 - 无机杂交涂层，用于生物医学应用

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> In the present work, the application of functional coatings on metallic implants was proposed to delay implant failure by improving tissue tolerance and implant osseointegration. Three bioactive and biocompatible organic–inorganic hybrid nanocomposites, consisting of polyethylene glycol (PEG) embedded in a SiO 2 , ZrO 2 , and TiO 2 matrix, respectively, were synthesized via the sol–gel method. Materials in the sol phase were used to dip‐coat titanium grade 4 substrates for use as dental and orthopedic implant models. To investigate the influence of the glass matrix and the polymer amount on the coating structure, and thus on their biological properties, several hybrids were obtained by adding different weight percentages of PEG to each glass matrix. Attenuated total reflectance Fourier transform infrared spectroscopy confirmed the presence of the polymer in the nanocomposites and scanning electron microscopy showed that an increase in the PEG content allows crack‐free coatings to be obtained. Moreover, the bioactivity and biocompatibility of both the uncoated and coated titanium implants were investigated and compared by an in vitro test. The results revealed that coated substrates have more enhanced biological performance than the uncoated ones. The bioactivity is not significantly affected by either the inorganic matrix or the PEG amount, whereas the presence of polymer makes the films more biocompatible. POLYM. ENG. SCI., 57:478–484, 2017. ? 2017 Society of Plastics Engineers
机译： >在本作的工作中，提出了通过改善组织来延迟植入物失效的金属植入物上的应用耐受性和植入骨整合。三种生物活性和生物相容性有机 - 无机杂交纳米复合材料，其由嵌入SiO 2 ，ZrO 2 和TiO 2 的聚乙二醇（PEG）组成分别通过溶胶 - 凝胶法合成基质。溶胶相中的材料用于浸涂钛料级4基底以用作牙科和整形外科植入模型。为了研究玻璃基质和聚合物量对涂层结构的影响，因此通过将不同的重量百分比的PEG加入每个玻璃基质来获得几种杂种。减弱的总反射率傅里叶变换红外光谱证实了纳米复合材料中的聚合物的存在，并且扫描电子显微镜表明PEG含量的增加允许获得无裂缝的涂层。此外，通过在体外测定中研究并比较了未涂覆和涂覆的钛植入物的生物活性和生物相容性。结果表明，涂​​覆的基材具有比未涂覆的涂覆的生物学性能更高。生物活性不会受到无机基质或PEG量的显着影响，而聚合物的存在使膜更加生物相容性。聚合物。 eng。 SCI。，57：478-484,2017。？ 2017年塑料工程师协会

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