...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Platelets >Pathogen reduction technologies: The pros and cons for platelet transfusion
【24h】

Pathogen reduction technologies: The pros and cons for platelet transfusion

机译：病原体减少技术：血小板输血的利弊

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The transfusion of platelets is essential for diverse pathological conditions associated with thrombocytopenia or platelet disorders. To maintain optimal platelet quality and functions, platelets are stored as platelet concentrates (PCs) at room temperature under continuous agitationconditions that are permissive for microbial proliferation. In order to reduce these contaminants, pathogen reduction technologies (PRTs) were developed by the pharmaceutical industry and subsequently implemented by blood banks. PRTs rely on chemically induced cross-linking and inactivation of nucleic acids. These technologies were initially introduced for the treatment of plasma and, more recently, for PCs given the absence of a nucleus in platelets. Several studies verified the effectiveness of PRTs to inactivate a broad array of bacteria, viruses, and parasites. However, the safety of PRT-treated platelets has been questioned in other studies, which focused on the impact of PRTs on platelet quality and functions. In this article, we review the literature regarding PRTs, and present the advantages and disadvantages related to their application in platelet transfusion medicine.
机译：血小板输血对于与血小板减少症或血小板疾病相关的不同病理病症至关重要。为了保持最佳的血小板质量和功能，在允许微生物增殖的连续搅拌条件下在室温下储存血小板作为血小板浓缩物（PC）。为了减少这些污染物，通过制药行业开发了病原体减少技术（PRTS），随后由血库实施。 PRTS依赖于化学诱导的交联和核酸的灭活。最初引入这些技术用于治疗血浆，并且最近，对于血小板中没有核的核心，更近于PC。若干研究验证了PRTS以灭活广泛的细菌，病毒和寄生虫的有效性。然而，PRT治疗的血小板的安全性在其他研究中受到质疑，其重点是PRTS对血小板质量和功能的影响。在本文中，我们审查了有关PRT的文献，并呈现与其在血小板输血中的应用相关的优缺点。

著录项

  • 来源
    《Platelets》 |2018年第1期|共7页
  • 作者

    Magron Audrey; Laugier Jonathan; Provost Patrick; Boilard Eric;

  • 作者单位

    Univ Laval Fac Med Ctr Hosp Univ Quebec Ctr Rech Dept Microbiol &

    Immunol Quebec City PQ;

    Univ Laval Fac Med Ctr Hosp Univ Quebec Ctr Rech Dept Microbiol &

    Immunol Quebec City PQ;

    Univ Laval Fac Med Ctr Hosp Univ Quebec Ctr Rech Dept Microbiol &

    Immunol Quebec City PQ;

    Univ Laval Fac Med Ctr Hosp Univ Quebec Ctr Rech Dept Microbiol &

    Immunol Quebec City PQ;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 基础医学;
  • 关键词

    platelets; transfusion; pathogen reduction systems;

    机译：血小板;输血;病原体还原系统;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号