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首页> 外文期刊>Prevention science: the official journal of the Society for Prevention Research >Transactions Between Substance Use Intervention, the Oxytocin Receptor ( OXTR ) Gene, and Peer Substance Use Predicting Youth Alcohol Use
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Transactions Between Substance Use Intervention, the Oxytocin Receptor ( OXTR ) Gene, and Peer Substance Use Predicting Youth Alcohol Use

机译：物质使用干预之间的交易，催产素受体（OXTR）基因，以及同次物质使用预测青年酒精使用

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Abstract This study investigated the oxytocin receptor ( OXTR ) genes moderation of associations between exposure to a substance misuse intervention, average peer substance use, and adolescents own alcohol use during the 9th-grade. OXTR genetic risk was measured using five single nucleotide polymorphisms (SNPs), and peer substance use was based on youths nominated closest friends own reports of alcohol, cigarette, and marijuana use, based on data from the PROSPER project. Regression models revealed several findings. First, low OXTR risk was linked to affiliating with friends who reported less substance use in the intervention condition but not the control condition. Second, affiliating with high substance-using friends predicted youth alcohol risk regardless of OXTR risk or intervention condition. Third, although high OXTR risk youth in the intervention condition who associated with low substance-using friends reported somewhat higher alcohol use than comparable youth in the control group, the absolute level of alcohol use among these youth was still among the lowest in the sample.
机译：摘要本研究研究了催产素受体（OXTR）基因在暴露于物质滥用干预，平均等物质使用和青少年期间在第9级的饮酒中使用的催产素受体（OXTR）基因。使用五种单一核苷酸多态性（SNP）测量OXTR遗传风险，并且基于青少年使用的同伴使用最亲密的朋友在繁荣项目中的数据基础上获得最接近的酒精，香烟和大麻使用的报告。回归模型揭示了几种结果。首先，较低的oxtr风险与与报告介入条件下的物质较少而且没有控制条件的朋友的联系方式相关联。其次，隶属于使用高质物质的亲属预测青少年酒精风险，无论oxtr风险还是干预条件。第三，虽然高奥风险青年在与低质物质的朋友相关的干预条件下，但使用对照组的可比较青年的酒精使用稍高，但这些青年中的酒精使用的绝对水平仍然是样本中最低的。

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