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Targeting prion protein interactions in cancer

机译：靶向朊病毒蛋白蛋白质在癌症中的相互作用

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In recent years, prion protein (PrPC) has been considered as a promising target molecule for cancer therapies, due its direct or indirect participation in tumor growth, metastasis, and resistance to cell death induced by chemotherapy. PrPC functions as a scaffold protein, forming multiprotein complexes on the plasma membrane, which elicits distinct signaling pathways involved in diverse biological phenomena and could be modulated depending on the cell type, complex composition, and organization. In addition, PrPC and its partners participate in self-renewal of embryonic, tissue-specific stem cells and cancer stem cells, which are suggested to be responsible for the origin, maintenance, relapse, and dissemination of tumors. Interference with protein-protein interaction has been recognized as an important therapeutic strategy in cancer; indeed, the possible interference in PrPC engagement with specific partners is a novel strategy. Recently, our group successfully used that approach to interfere with the interaction between PrPC and HSP-90/70 organizing protein (HOP, also known as stress-inducible protein 1 - STI1) to control the growth of human glioblastoma in animal models. Thus, PrPC-organized multicomplexes have emerged as feasible candidates for anti-tumor therapy, warranting further exploration.
机译：近年来，朊病毒蛋白（PRPC）被认为是癌症疗法的有希望的靶分子，因为它直接或间接地参与肿瘤生长，转移和对化学疗法诱导的细胞死亡的抵抗力。 PRPC用作支架蛋白质，形成血浆膜上的多素蛋白复合物，其引起不同的生物现象中涉及的不同信号通路，并且可以根据细胞类型，复杂的组合和组织进行调节。此外，PRPC及其合作伙伴参与了胚胎，组织特异性干细胞和癌症干细胞的自我更新，这表明该肿瘤的起源，维持，复发和传播负责。对蛋白质 - 蛋白质相互作用的干扰已被认为是癌症中重要的治疗策略;实际上，PRPC与特定合作伙伴的可能干扰是一种新的策略。最近，我们的团体成功地使用这种方法干扰PRPC和HSP-90/70组织蛋白（啤酒花，也称为应激诱导蛋白1 - STI1）之间的相互作用，以控制动物模型中人胶质母细胞瘤的生长。因此，PrPC组织的多相复杂是抗肿瘤治疗的可行候选者，需要进一步探索。

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