Preliminary evaluation

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Preliminary evaluation

机译：初步评估

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In two non-comparative trials in patients with T790M mutation-positive non-small cell lung cancer, osimertinib reduced tumour size in about two-thirds of patients. But a link between tumour shrinkage and prolonged survival has not been demonstrated. Like other tyrosine kinase inhibitors, osimertinib provokes frequent and sometimes serious adverse effects. In practice, it is only reasonable to use osimertinib in the clinical trial setting.

机译：在T790M突变阳性非小细胞肺癌患者的两项非比较试验中，Osimertinib在约三分之二的患者中减少了肿瘤大小。但肿瘤收缩与长期存活之间的联系尚未得到证实。与其他酪氨酸激酶抑制剂一样，Osimertinib激发频繁，有时是严重的不良反应。在实践中，在临床试验环境中使用OSIMERTINIB只有合理。

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《Prescrire international》 |2017年第183期|共2页
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