pembrolizumab (keytruda0) and metastatic or inoperable melanoma - A nivolumab me-too

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pembrolizumab (keytruda0) and metastatic or inoperable melanoma - A nivolumab me-too

机译：Pembrolizumab（Keytruda0）和转移性或无法操作的黑色素瘤 - 一种Nivolumab me-so

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Pembrolizumab, which has the same pharmacological mechanism as nivolumab, has not been properly evaluated in treatment-naive patients with metastatic or inoperable melanoma. When ipilimumab fails, there is no evidence that pembrolizumab prolongs survival as compared to cytotoxic drugs. Its known adverse effects are similar to those of nivolumab.

机译：具有与Nivolumab相同的药理学机制的Pembrolizumab尚未在治疗 - 天真的转移或不可操作的黑色素瘤患者中进行适当评估。当IPILIMIMAB失败时，与细胞毒性药物相比，没有证据表明PEMBROLIZUMAB延长存活。其已知的不良反应类似于Nivolumab的不利影响。

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《Prescrire international》 |2017年第182期|共2页
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1. pembrolizumab (keytruda0) and metastatic or inoperable melanoma - A nivolumab me-too [J] . Prescrire international . 2017,第182期

机译：Pembrolizumab（Keytruda0）和转移性或无法操作的黑色素瘤 - 一种Nivolumab me-so
2. Safe Administration of Ipilimumab, Pembrolizumab, and Nivolumab in a Patient with Metastatic Melanoma, Psoriasis, and a Previous Guillain–Barré Syndrome [J] . Alessio Cortellini, Alessandro Parisi, Maria Concetta Fargnoli, Case Reports in Oncological Medicine . 2018,第2期

机译：对患有转移性黑素瘤，牛皮癣和先前的格林-巴雷综合征的患者进行安全管理的依匹木单抗，派姆单抗和尼武单抗
3. Healthcare resource utilization in patients with metastatic melanoma receiving first-line therapy with dabrafenib plus trametinib versus nivolumab or pembrolizumab monotherapy [J] . Ghate Sameer R., Ionescu-Ittu Raluca, Burne Rebecca, Current medical research and opinion . 2018,第12期

机译：用Dabrafenib Plus Trametinib与Nivolumab或Pembrolizumab单药治疗患者转移黑色素瘤患者的医疗资源利用
4. CELL COMMUNICATION NETWORK FACTOR 4 (CCN4/WISP1) SHIFTS MELANOMA CELLS FROM A FRAGILE PROLIFERATIVE TO A RESILIENT METASTATIC STATE AND SUPPRESSES IMMUNE SURVEILLANCE [C] . David J. Klinke II, Wentao Deng, Audry Fernandez Conference on biochemical and molecular engineering . 2019

机译：细胞通信网络因子4（CCN4 / WISP1）将黑色素瘤细胞从脆弱的增殖状态转变为弹性的转移状态，并抑制了免疫监视
5. The Role of TEADs1-4 in YAP/TAZ-Mediated Metastatic Melanoma [D] . Kalkur, Roshni S. 2020

机译：Tead1-4在YAP / TAZ介导的转移性黑色瘤中的作用
6. Safe Administration of Ipilimumab, Pembrolizumab, and Nivolumab in a Patient with Metastatic Melanoma, Psoriasis, and a Previous Guillain–Barré Syndrome [O] . Alessio Cortellini, Alessandro Parisi, Maria Concetta Fargnoli, 1908

机译：对患有转移性黑素瘤，牛皮癣和先前的格林-巴雷综合征的患者进行安全管理的依匹木单抗，派姆单抗和尼武单抗
7. Healthcare resource utilization in patients with metastatic melanoma receiving first-line therapy with dabrafenib + trametinib versus nivolumab or pembrolizumab monotherapy [O] . Sameer R. Ghate, Raluca Ionescu-Ittu, Rebecca Burne, 2018

机译：用DabrafeNib + Trametinib与Nivolumab或Pembrolizumab单药治疗患者转移性黑素瘤患者的医疗资源利用

pembrolizumab (keytruda0) and metastatic or inoperable melanoma - A nivolumab me-too

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