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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Increasing colorectal cancer incidence trends among younger adults in Canada
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Increasing colorectal cancer incidence trends among younger adults in Canada

机译：增加加拿大年幼成年人的结直肠癌发生率趋势

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Abstract Recent analyses in the United States have shown an overall decrease in the incidence of colorectal cancer despite contrasting increases in younger age groups. We examined whether these cohort trends are occurring in Canada. Age-specific trends in colon and rectal cancer incidence in Canada from the National Cancer Incidence Reporting System (1969–1992) and the Canadian Cancer Registry (1992–2012) were analyzed. We estimated annual percent changes (APC) with the Joinpoint Regression Program from the Surveillance Epidemiology, and End Results Program. Birth cohort effects were estimated using 5-year groups starting in 1888. Age-specific prevalence of class I, II and III obesity in Canada was examined from the National Population Health Survey (1994–2001) and the Canadian Community Health Survey (2001–2011). The reductions in CRC incidence among Canadians are limited to older populations. While reductions among younger age groups (20–29year olds (yo), 30–39yo and 40–50yo) were observed between 1969 and 1995, rates have returned to and surpassed historical levels (APCs 20–29yo colon cancer=6.24%, APCs 20–29yo rectal cancer=1.5%). Recent birth cohorts (1970–1990) have the highest incidence rate ratios ever recorded. Ecologic trends in obesity prevalence among these birth cohorts in Canada are suggestive of an impact on increasing incidence trends. Furthermore, obesity prevalence estimates suggest that these trends may continue to increase justifying further examination of the etiologic associations and biological impacts of excess adipose tissue among younger populations. While population-based screening of younger age groups deserves careful consideration, these concerning observed trends warrant public health action to address the growing obesity epidemic. Highlights ? Colorectal cancer incidence in Canada is decreasing in older populations. ? However, there is a significant increase in incidence in adults under 50years old. ? Increasing incidence in younger adults may be associated with increasing obesity.
机译：摘要尽管较年轻的年龄群体增加，但美国最近的分析表明结肠直肠癌发生率的总体下降。我们审查了加拿大是否正在发生这些裁讨论趋势。来自国家癌症发病率报告系统（1969-1992）和加拿大癌症登记处（1992-2012）的年龄特异性趋势和直肠癌发病率。我们从监视流行病学的加入点回归计划和最终结果计划估计年度百分比变化（APC）。从1888年开始，使用5年群估计出生队列效应。从国家人口卫生调查（1994-2001）和加拿大社区卫生调查（2001年）审查了加拿大II，II和III肥胖的年龄特异性患病率（2001年）（2001年） 2011）。加拿大人CRC发病率的减少仅限于较老的人口。在1969年至1995年间观察到较年轻的年龄组（20-29岁的老人（yo），30-39yo和40-50yo）之间的减少，率已经恢复并超越了历史水平（APCS 20-29YO结肠癌= 6.24％，APC 20-29YO直肠癌= 1.5％）。最近的出生队列（1970-1990）的发病率率最高。加拿大这些出生队列之间的肥胖患病率的生态趋势暗示了对日益增长的趋势的影响。此外，肥胖普遍估计表明，这些趋势可能会继续增加对年轻人群中过量脂肪组织的病因关联和生物学冲击的公正检查。虽然基于人口的筛查年龄群体的筛查值得仔细考虑，但这些关于观察到的趋势需要公共卫生行动，以解决不断增长的肥胖流行病。强调 ？加拿大的结肠直肠癌发病率降低了较老的人群。还然而，在50年龄较小的成人下发生的发生率显着增加。还较年轻的成年人的发病率增加可能与肥胖增加有关。

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