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首页> 外文期刊>Preventive Medicine: An International Journal Devoted to Practice and Theory >Adverse childhood experiences, internalizing/externalizing symptoms, and associated prescription opioid misuse: A mediation analysis
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Adverse childhood experiences, internalizing/externalizing symptoms, and associated prescription opioid misuse: A mediation analysis

机译：不利的童年经验，内化/外化症状，以及相关的处方表述滥用：调解分析

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Adverse childhood experiences (ACEs) are associated with mental health and substance use problems, but lesser known is how they interconnect. The objective of this study was to examine how internalizing and externalizing symptoms mediate the association of ACEs with prescription opioid misuse in order to understand how ACEs interconnect with mental health and substance use problems. Adults aged 18 or older from the National Epidemiological Survey on Alcohol and Related Conditions Wave 3 (NESARC-III) conducted in 2012-2013 were included (N = 36,309). The prescription opioid misuse outcomes examined include prescription opioid misuse status, early-onset status of prescription opioid misuse, frequency of past-year prescription opioid misuse, and opioid use disorder. A natural effect model and regression analyses were used to conduct the mediation analyses. We found that respondents with higher ACE scores had greater odds of reporting past-year and lifetime prescription opioid misuse and DSM-V-diagnosed opioid use disorder as well as early onset of prescription opioid misuse (AORs range from 1.06 to 1.12). These associations are partially mediated by internalizing and externalizing symptoms. The findings suggest that internalizing and externalizing symptoms may be potential pathways through which ACEs are associated with prescription opioid misuse. Our results underscore the importance of preventing ACEs and reducing risk for internalizing and externalizing symptoms after exposure, which may reduce later prescription opioid misuse.
机译：不利的童年经历（ACE）与心理健康和物质使用问题有关，但鲜为人知的是它们是如何互连的。本研究的目的是探讨内化和外化症状如何介导ACE与处方阿片类药物滥用的关联，以了解ACES与心理健康和物质使用问题的互连。 18岁或以上的成年人来自国家流行病学调查，包括2012-2013波动（NESARC-III）（n = 36,309）。检测的处方阿片类药物滥用结果包括处方阿片类药物滥用状态，处方阿片类药物滥用的早期发病状态，过去年度处方阿片类药物滥用的频率和阿片类药物使用障碍。使用自然效果模型和回归分析来进行中介分析。我们发现，具有较高ACE评分的受访者报告过去一年和终身处方阿片类药物滥用和DSM-V诊断的阿片类药物使用障碍以及处方阿片类药物误用的早期发病（AOR的缺陷率为1.06至1.12）。这些关联部分通过内化和外化症状部分介导。研究结果表明，内化和外化症状可能是潜在的途径，ACES与处方阿片类药物滥用相关的潜在途径。我们的结果强调了在暴露后防止aces和减少内化和外化症状的风险的重要性，这可能会减少后期的处方阿片类药物滥用。

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