P1GF isoform 3 in maternal serum and placental tissue

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P1GF isoform 3 in maternal serum and placental tissue

机译：P1GF同种型3母体血清和胎盘组织

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Objectives: Four isoforms originating from alternative splicing of PGF gene have been reported for placental growth factor (PlGF). Main PlGF isoforms 1 and 2 have been associated with screening and diagnosis of pre-eclampsia (PE). Despite of the vast amount of research around PlGF in PE, protein levels of isoforms P1GF-3 and -4 have not been reported in human serum samples.Study design: In this study a PlGF-3 specific DELFIA research immunoassay based on a custom recombinant Fab binder was developed and characterized. Serum levels of a third PlGF isoform during pregnancy were determined and screening performance of PlGF-3 for PE and small for gestational age (SGA) was investigated. Main outcome measures: Levels of serum and placental tissue PlGF 3 and predictive power of PlGF-3 for Pre-eclampsia and SGA.

机译：目的：据报道，胎盘生长因子（PLGF）据报道源自PGF基因的替代剪接的四种同种型。主要的PLGF同种型1和2与预痫前的筛选和诊断有关。尽管在PE的PLGF周围有大量的研究，但在人血清样品中尚未报告同种型P1GF-3和-4的蛋白质水平 Fab Binder开发并表征。研究了妊娠期间第三种PLGF同种型的血清水平，并确定了PLGF-3的性能，对PE和小于妊娠期（SGA）进行了研究。主要观察措施：血清和胎盘组织PLGF 3和PLGF-3的预测力，用于预痫，对异常癌症和SGA。

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《Pregnancy hypertension》 |2019年第2019期|共5页
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正文语种 eng
中图分类妇产科学;
关键词
Placental growth factor; Isoform; DELFIA; Pre-eclampsia; Small for gestational age;

机译：胎盘生长因子;同种型;Delfia;预先揭露;小于胎龄;

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专利

1. P1GF isoform 3 in maternal serum and placental tissue [J] . Pregnancy hypertension . 2019,第期

机译：P1GF同种型3母体血清和胎盘组织
2. Maternal serum placental growth factor isoforms 1 and 2 at 11-13, 20-24 and 30-34 weeks' gestation in late-onset pre-eclampsia and small for gestational age neonates [J] . NucciM., PoonL.C., DemirdjianG., Fetal diagnosis and therapy . 2014,第4期

机译：晚期子痫前期妊娠时孕妇的胎盘血清胎盘生长因子同工型1和2在妊娠11-13、20-24和30-34周时较小，而对于胎龄新生儿则较小
3. SHBG in GDM maternal serum, placental tissues and umbilical cord serum expression changes and its significance [J] . SunL., JinZ., TengW., Diabetes research and clinical practice . 2013,第2期

机译：GDM孕妇血清，胎盘组织和脐血中SHBG的表达变化及其意义
4. Relationship between Polybrominated Diphenyl Ether (PBDE) Levels in Maternal Serum and Fetal Tissues during Mid-Gestation of Pregnancy and Associations with Placental Biomarkers of Growth and Development [C] . Julia Varshavsky, Kenisha Williams Puckett, Josh Robinson, Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology . 2018

机译：孕妇中期妊娠期间母体血清和胎儿组织中多溴二苯醚（PBDE）水平之间的关系以及与胎盘生长和发育生物标志物的关联
5. Relationship Between the Changes in Placental Blood Flow Resistance Assessed by Doppler Technique and Maternal Serum Placental Aminopeptidases, which Degrade Vaso-Active Peptides, in Pre-Eclampsia [D] . ASADA Y, MIZUTANI S, KASUGAI M, 1992

机译：多普勒技术评估的子痫前期胎盘血流阻力变化与母体血清胎盘氨基肽酶（降低血管活性肽）之间的关系
6. First Trimester Pregnancy Loss and the Expression of Alternatively Spliced NKp30 Isoforms in Maternal Blood and Placental Tissue [O] . Avishai Shemesh, Dan Tirosh, Eyal Sheiner, 2015

机译：孕早期妊娠流产以及母体血液和胎盘组织中其他剪接的NKp30亚型的表达
7. First Trimester Pregnancy Loss and the Expression of alternatively spliced NKp30 isoforms in Maternal Blood and Placental Tissue [O] . Avishai eShemesh, Dan eTirosh, Eyal eSheiner, 2015

机译：妊娠早期妊娠丢失和母体血液和胎盘组织中可变剪接的NKp30同种型的表达

P1GF isoform 3 in maternal serum and placental tissue

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