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首页> 外文期刊>Pregnancy hypertension >Human Immunodeficiency Virus and risk of pre-eclampsia and eclampsia in pregnant women: A meta-analysis on cohort studies
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Human Immunodeficiency Virus and risk of pre-eclampsia and eclampsia in pregnant women: A meta-analysis on cohort studies

机译：孕妇中患有先兆子痫和异普拉明裔的人类免疫缺陷病毒与普利坦克西亚的风险：队列研究的荟萃分析

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Maternal HIV infection is related to several perinatal adverse outcomes. This study is aimed at establishing whether maternal HIV infection is associated with the development of pre-eclampsia (PE) and eclampsia. We comprehensively searched MEDLINE/PubMed, Web of Science, SCOPUS and Embase databases for relevant studies published up to 20 November 2018, without time and language restrictions. We have limited our literature searches to observational studies in humans. We applied a random-effects model to calculate the relative risks (RR) and 95% confidence intervals (CI) for the meta-analyses. We also systematically reviewed eligible studies to determine the effects of HIV infection on imbalance of angiogenic and anti-angiogenic factors, which are effective in increased risk of PE or eclampsia. We identified a total of 11,186 publications, out of which 22 eligible studies (11 prospective and 11 retrospective cohort studies) comprising 90,514 HIV-positive and 66,085,278 HIV-negative pregnant women were included in meta-analysis. Results of the meta-analyses suggested that maternal HIV infection is not significantly associated with the development of PE (RR, 1.04; 95%CI, 0.89-1.21) and eclampsia (RR, 1.05; 95%CI, 0.63-1.75). Six studies were included to understand the effects of HIV infection on imbalance of angiogenic and anti-angiogenic factors. All six studies demonstrated that HIV infection had no significant effect on expression levels of these factors in pre-eclamptic and normotensive pregnant women. Our study showed that maternal HIV infection was not significantly associated with increased or reduced risks of pre-eclampsia and eclampsia. More well-designed studies with large sample size and well defined outcomes are recommended to confirm or refute the present findings.
机译：母体HIV感染与几种围产期不良结果有关。本研究旨在建立母体艾滋病毒感染是否与先兆子痫（PE）和葛兰普查的发展有关。我们全面搜索了Medline / Pubmed，科学网络，Scopus和Embase数据库，以获得2018年11月20日发布的相关研究，没有时间和语言限制。我们有限于我们的文学搜索对人类的观察研究。我们应用了随机效应模型来计算Meta分析的相对风险（RR）和95％置信区间（CI）。我们还系统性地审查了合格的研究，以确定HIV感染对血管生成和抗血管生成因子不平衡的影响，这对于PE或Eclampsia的风险有效。我们确定了11,186个出版物，其中22个符合条件的研究（11个前瞻性和11个回顾性队列研究），其包含90,514个HIV阳性和66,085,278名HIV阴性孕妇的荟萃分析。荟萃分析的结果表明，母体HIV感染与PE的发育没有显着相关（RR，1.04; 95％CI，0.89-1.21）和葛兰素（RR，1.05; 95％CI，0.63-1.75）。包括六项研究，以了解HIV感染对血管生成和抗血管生成因子不平衡的影响。所有六项研究表明，艾滋病毒感染对先生和正常孕妇的这些因素的表达水平没有显着影响。我们的研究表明，母亲HIV感染没有显着相关或降低出版前预痫对象和异国葡萄球菌的风险。建议使用大型样品尺寸和明确结果进行更精心设计的研究来确认或反驳现有结果。

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