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首页> 外文期刊>Pregnancy hypertension >Differences in the prognosis of preeclampsia according to the initial symptoms: A single-center retrospective report
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Differences in the prognosis of preeclampsia according to the initial symptoms: A single-center retrospective report

机译：根据初始症状的预坦克敏预测的差异：单中心回顾报告

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Preeclampsia (PE) is a disease with a combination of hypertension and proteinuria, and the incidence is reported to be 3-5% [1,2]. PE is the cause of 63,000 maternal and fetal deaths globally [3] and one of the primary causes of premature births. The details of the etiology of PE are still unknown; however, a two-stage disorder theory [4] has been proposed, and these details are on the verge of being elucidated. PE onset proceeds in the following order: immunogenic maladaptation, poor placentation and subsequent impairment of spiral artery remodeling, increased production of antiangiogenic factors (soluble fms-like tyrosine kinase-1 [sFlt-1] and soluble endoglin [sEng]) by the chorionic villi, migration of antiangiogenic factors to the fetal and maternal circulations, accompanied by vascular endothelial damage onset. Eventually, hypertension and proteinuria develop in the mother, while intrauterine growth restriction, fetal dysfunction, etc., develop in the fetus [5].
机译：预口度（PE）是一种具有高血压和蛋白尿的组合的疾病，发病率为3-5％[1,2]。 PE是全球63,000名母亲和胎儿死亡的原因[3]以及早产的主要原因之一。 PE病因的细节仍然未知; 然而，提出了两级障碍理论[4]，这些细节正在阐明。 PE发作按以下顺序进行：免疫原性不良的诱导，沉默性差，随后对螺旋动脉重塑的损害，增加抗原因子的产生（可溶性FMS样酪氨酸激酶-1 [SFLT-1]和可溶性endoglin [Seng]）通过绒毛膜 villi，迁移到胎儿和母体循环的抗原因素，伴有血管内皮损伤发病。 最终，高血压和蛋白尿在母亲中发育，而宫内生长限制，胎儿功能障碍等，在胎儿中发育[5]。

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